Structure-Function Relationship of Antitumor β-1,3-Glucan Obtained from Matted Mycelium of Cultured Grifola frondosa
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概要
- 論文の詳細を見る
The structure-function relationship of the antitumor 6-branched β-1,3-glucan (grifolan NMF-5N) extracted from the matted mycelium of Grifola frondosa was examined by using various chemical modification procedures (periodate oxidation, Smith degradation, and enzymic hydrolysis). The antitumor activity of grifolan NMF-5N was not lowered by periodate oxidation. Partial removal of branches by mild hydrolysis did not affect the activity. However, the linear β-1,3-glucan obtained by Smith degradation lacked antitumor activity. From the results of enzymic hydrolysis of grifolan NMF-5N, this glucan contains a β-1,3-glucanase-resistant core structure. The core structure is present randomly in this glucan, and does not itself show antitumor activity. These results suggest that some of the branches at C-6 in grifolan NMF-5N are important for the antitumor activity, and that the activity requires a relatively high molecular weight.
- 社団法人日本薬学会の論文
- 1985-11-25
著者
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大野 尚仁
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
東京薬科大学
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佐藤 吉朗
Nippon Beet Sugar Mfg. Co. Ltd.
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大野 尚仁
東京薬科大学免疫学
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及川 昭蔵
Nippon Beet Sugar Mfg. Co. Ltd.
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鈴木 巌
Tokyo College of Pharmacy
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鈴木 巖
Tokyo College of Pharmacy
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飯野 一義
Tokyo College of Pharmacy
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Ohno N
Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of
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