Structure and Antitumor Activity of a β-1,3-Glucan Isolated from the Culture Filtrate of Sclerotinia sclerotiorum IFO 9395
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概要
- 論文の詳細を見る
An antitumor glucan (SSG) was isolated from the culture filtrate of Sclerotinia sclerotiorum IFO 9395 by sequential use of ethanol precipitation, ion exchange chromatography on diethyl-aminoethyl-Sephadex A-25,and precipitation with ammonium sulfate. From the results of methylation analysis and carbon-13 nuclear magnetic resonance spectroscopy, SSG was concluded to be a β-1,3-D-glucan branched at position 6 of every two 3-substituted β-glucosyl units. SSG formed a complex with congo red in dilute alkali solution, and showed potent antitumor activity against the solid form of sarcoma 180 in ICR mice.
- 公益社団法人日本薬学会の論文
- 1986-03-25
著者
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大野 尚仁
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
東京薬科大学
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大野 尚仁
東京薬科大学免疫学
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大野 尚仁
帝京大学 医学部微生物学講座
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鈴木 巖
Tokyo College of Pharmacy
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Ohno N
Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of
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