Physicochemical Properties and Immunomodulating Activities of Hot Water Extract from Sclerotia of Sclerotinia sclerotiorum IFO 9395(Biological)
スポンサーリンク
概要
- 論文の詳細を見る
The physicochemical properties and immunomodulating activities of a hot water extract (TSHW) from the sclerotia of Sclerotinia sclerotiorum IFO 9395 were examined. S. sclerotiorum IFO 9395 produced 5-8g (dry weight) of sclerotia per 100 agar plates (9cm diameter). The non-dialyzable fraction of a hot water extract from the sclerotia (TSHW, yield 11-17%) was composed of protein 20-40%, carbohydrate 60-70%, and a trace of phosphate. Major carbohydrate components were glucose and mannose in a molar ratio of 1.0:0.7 (±0.3) (mean±S.D.). TSHW was mitogenic to murine spleen cells but not to thymus cells. The mitogenic activity was also observed in C3H/HeJ mice spleen cells. TSHW activated the murine spleen cells to antibody-forming cells polycionally. Carbon clearance activity was also activated by intraperitoneal injection of TSHW. TSHW also showed antitumor activity against the solid form of sarcoma 180 tumor in ICR mice. These results suggest that the sclerotia from Sclerotinia sclerotiarum contain materials showing various immunomodulating activities.
- 公益社団法人日本薬学会の論文
- 1986-12-25
著者
-
大野 尚仁
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
-
宿前 利郎
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
-
宿前 利郎
東京薬科大学
-
大野 尚仁
東京薬科大学免疫学
-
大野 尚仁
帝京大学 医学部微生物学講座
-
篠原 久実
Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy
-
篠原 久実
Tokyo College of Pharmacy
-
Ohno N
Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of
-
篠原 久実
Laboratory Of Immunopharmacology Of Microbial Products Tokyo College Of Pharmacy
関連論文
- 薬学部新入学生の早期体験実習におけるKJ法を用いたスモールグループディスカッションの有用性
- CAWS血管炎惹起の分子メカニズム
- Inactivation of (1→3)-β-D-Glucan in Mice
- Modulation of the Antitumor Effect and Tissue Distribution of Highly Branched (1→3)-β-D-Glucan, SSG, by Carrageenan
- Relationship between the Tissue Distribution and Antitumor Activity of Highly Branched (1→3)-β-D-Glucan, SSG
- Structure-Activity Relationship of (1→3)-β-D-Glucans in the Induction of Cytokine Production from Macrophages, in Vitro
- Comparison of the Immunopharmacological Activities of Triple and Single-Helical Schizophyllan in Mice
- D-11 漢方薬熱水抽出過程での成分間相互作用への遊離アミノ酸ならびに単糖の関与
- Resistance of Highly Branched (1→3)-β-D-Glucans to Formolysis
- Structural Analysis of Alkaline-Soluble Polysaccharide, P-1,from the Kernels of Prunus mume SIEB. et ZUCC.
- Comparison of the Blood Clearance of Triple- and Single-Helical Schizophyllan in Mice
- Enhancement of LPS Triggered TNF-α (Tumor Necrosis Factor-α) Production by (1→3)-β-D-Glucans in Mice
- Enhancement of Cytokine Production by Macrophages Stimulated with (1→3)-β-D-Glucan, Grifolan (GRN), Isolated from Grifola frondosa
- Preparation and Antigen Specificity of an Anti-(1→3)-β-D-glucan Antibody
- Analysis of Cytokine mRNAs Induced by the Administration of a Highly Branched (1→3)-β-D-Glucan, OL-2
- Changes in Immune Mediators in Mouse Lung Produced by Administration of Soluble (1→3)-β-D-Glucan
- Biological Activity and Structural Characterization of Alkaline-Soluble Polysaccharides from the Kernels of Prunus mume SIEB. et ZACC.
- Expression of Interleukin 1 Family mRNAs by a Highly Branched (1→3)-β-D-Glucan, OL-2
- Application of Limulus Test (G Pathway) for the Detection of Different Conformers of (1→3)-β-D-Glucans
- Inhibitory Effect of β-Glucans on Zymosan-Mediated Hydrogen Peroxide Production by Murine Peritoneal Macrophages in Vitro
- Immunopharmacological Characterization of a Highly Branched Fungal (1→3)-β-D-Glucan, OL-2,Isolated from Omphalia lapidescens
- Binding of Lysozyme to Synthetic Monosaccharide Lipid A Analogue, GLA60
- SY1-4 免疫疾患に関わる真菌多糖と自然免疫受容体(真菌と免疫・アレルギー,シンポジウム1,医真菌学のコペルニクス的転回を目指して)
- P-071 シクロフォスファミド投与白血球減少症モデルマウスにおけるCandida由来PAMPsへの応答性の検討(免疫・アレルギー,ポスター討論,一般演題,医真菌学のコペルニクス的転回を目指して)
- P-072 真菌症患者血清における抗β-グルカン抗体のβ1,3/β1,6構造に対する反応性の比較(免疫・アレルギー,ポスター討論,一般演題,医真菌学のコペルニクス的転回を目指して)
- 血管炎発症に関わる活性化好中球MPO分子の蛍光ナノ粒子による検出
- 01P2-006 DBA/2系マウスに惹起されるCAWS血管炎の心機能異常を伴う致死的病態モデルとしての有用性に関する検討(薬物療法(基礎と臨床),医療薬学の扉は開かれた)
- 免疫異常による腎臓血管傷害のイメージング
- P-153 ヒト抗β-グルカン抗体価の検討(6.服薬指導(入院・外来)2,医療薬学の未来へ翔(はばた)く-薬剤師の薬剤業務・教育・研究への能動的関わり-)
- 真菌細胞壁の構造と機能--受容体との関連も含めて (特集 糖尿病と真菌症--臨床免疫と分子生物学的アプローチ) -- (真菌に関する基礎的事項)
- ベアード・パーカー寒天培地とウサギ血しょうフィブリノーゲン寒天培地のJIS化について
- CAWSによって惹起される致死的血管炎モデル--CAWS惹起冠状動脈炎 (第1土曜特集 血管炎の基礎と臨床) -- (基礎)
- Serum Components Induce β-D-Glucan-Inhibitable Uptake of Zymosan Particles by Murine Peritoneal Macrophages
- Heat Induced Conformational Changes Generate Mitogenicity to Splenocytes by Sclerogen from Sclerotinia sclerotiorum IFO 9395
- Physicochemical Characteristics and Antitumor Activities of a Highly Branched Fungal (1→3)-β-D-Glucan, OL-2,Isolated from Omphalia lapidescens
- Intravenously Administered (1→3)-β-D-Glucan, SSG, Obtained from Sclerotinia sclerotiorum IFO 9395 Augments Murine Peritoneal Macrophage Functions in Vivo
- Solubilization of Limulus Test Reactive Material(s) from Candida Cells by Murine Phagocytes
- Activation of Complement and Limulus Coagulation Systems by an Alkali-Soluble Glucan Isolated from Omphalia lapidescens and Its Less-Branched Derivatives. (Studies on Fungal Polysaccharide. XXXIX)
- Structure and Antitumor Activity of the Less-Branched Derivatives of an Alkali-Soluble Glucan Isolated from Omphalia lapidescens. (Studies on Fungal Polysaccharide. XXXVIII)
- Inhibition of Expeirmental Pulmonary Metastasis of Lewis Lung Carcinoma by Orally Administered β-Glucan in Mice
- Isolation of Mitogenic Substance from Sclerotia of Sclerotinia sclerotiorum IFO 9395 Extracted with Phosphate Buffer
- 薬学生のための免疫の本
- Effect of Intraperitoneally Administered β-1,3-Glucan, SSG, Obtained from Sclerotinia sclerotiorum IFO 9395 on the Functions of Murine Alveolar Macrophages
- Preparation and Antitumor Activity of Hydroxyethylated Derivatives of 6-Branched (1→3)-β-D-Glucan, SSG, Obtained from the Culture Filtrate of Sclerotinia sclerotiorum IFO 9395
- Heat Induced Generation of the Mitogenic Substance(s) Responding to Murine Splenocytes Obtained from Sclerotia of Sclerotinia sclerotiorum IFO 9395
- Macrophage Activation in Vitro by Chemically Cross-Linked (1→3)-β-D-Glucans
- Change of Biological Activities of (1→3)-β-D-Glucan from Grifola frondosa upon Molecular Weight Reduction by Heat Treatment
- Separation of the Hot Water Extracts of Sclerotia of Sclerotinia sclerotiorum IFO 9395 into Mitogenic and Antitumor-Active Subfractions
- Physicochemical Properties and Antitumor Activities of Chemically Modified Derivatives of Antitumor Glucan "Grifolan LE" from Grifola frondosa
- Antitumor and Immunomodulating Activities of a β-Glucan Obtained from Liquid-Cultured Grifola frondosa
- Rapid Measurement of Phagocytosis by Macrophages
- Dissociation of a Glucan Fraction (CO-1) from Protein-Bound Polysaccharide of Cordyceps ophioglossoides and Analysis of Its Antitumor Effect
- Conformation of Grifolan in the Fruit Body of Grifola frondosa Assessed by Carbon-13 Cross Polarization-Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy(Biological)
- Effect of Grifolan on the Ascites Form of Sarcoma 180(Biological)
- Conformational Changes of the Two Different Conformers of Grifolan in Sodium Hydroxide, Urea or Dimethylsulfoxide Solution(Biological)
- Effect of Activation or Blockade of the Phagocytic System on the Antitumor Activity of Grifolan
- Fractionation of Acidic Antitumor β-Glucan of Grifola frondosa by Anion-Exchange Chromatography Using Urea Solutions of Low and High Ionic Strengths
- Two Different Conformations of Antitumor Glucans Obtained form Grifola frondosa
- Effect of Glucans on the Antitumor Activity of Grifolan
- Characterization of the Antitumor Clucan Obtained from Liquid-Cultured Grifola frondosa
- Structure-Function Relationship of Antitumor β-1,3-Glucan Obtained from Matted Mycelium of Cultured Grifola frondosa
- Purification and Structural Characterization of an Antitumor β-1,3-Glucan Isolated from Hot Water Extract of the Fruit Body of Cultured Grifola frondosa
- Structural Characterization and Antitumor Activity of the Extracts from Matted Mycelium of Cultured Grifola frondosa
- Carbon-13 Nuclear Magnetic Resonance Spectral Analysis of the Fruit Bodies of Grifola frondosa
- Neutral and Acidic Antitumor Polysaccharides Extracted from Cultured Fruit Bodies of Grifola frondosa
- Antitumor Activity and Structural Characterization of Glucans Extracted from Cultured Fruit Bodies of Grifola frondosa
- Chemical Structure of Antitumor Polysaccharide, Coriolan, produced by Coriolus versicolor
- CAWS血管炎への Bruton's tyrosine kinase の関与に関する検討
- 肺胞マクロファージの真菌細胞壁成分によるNF-κB活性化ならびにサイトカイン発現誘導の検討
- ヒト抗β-グルカン抗体のクラス別力価と反応性
- 遺伝的素因の異なるマウスを用いたCAWS血管炎の検討
- 肺胞マクロファージの真菌細胞壁成分によるNF-κB活性化ならびにサイトカイン発現誘導の検討
- 真菌細胞壁多糖に対するマクロファージの応答性
- 真菌β-1,3-グルカンの構造と生物活性
- Structural Analysis of Glucan by Identification of Methylated Sugars by Proton Magnetic Resonance Spectra
- 微生物学基礎講座6 生理活性微生物化学, 大岳 望編, A5判, 248頁, 3,500円(共立出版)
- 続生化学実験講座4複合糖質研究法I, 日本生化学会 編, A5判, 368頁, 4,300円, (東京化学同人)
- ウエブスター菌類概論, ジョン・ウエブスター 著, 椿 啓介, 三浦宏一郎, 山本昌木 訳, A5判, 649頁, 12,000円, (講談社サイエンティフィク)
- 真菌多糖類の研究-31-スッポンタケ(Phallus impudicus)におけるglycuronanの局在性とその構造解析〔英文〕
- Chemical Characterization of a Fungal B-Cell Mitogen Obtained from the Fruit Body of Peziza vesiculosa
- Purification, Antitumor Activity, and Structural Characterization of β-1,3-Glucan from Peziza vesiculosa
- Antitumor Activity and Structural Characterization of Polysaccharide Fractions Extracted with Cold Alkali from a Fungus, Peziza vesiculosa
- Isolation of a Water-soluble Polysaccharide from the Mycelium of Penicillium chrysogenum (Studies on Fungal Polysaccharides. V)
- Carbon-13 Nuclear Magnetic resonance Spectroscopy of Some Edible Mushrooms
- Conformations of Fungal β-D-Glucans in the Fruit Body of Edible Fungi Assessed by Gross Polarization-Magic Angle Spinning Carbon-13 Nuclear Magnetic Resonance Spectroscopy
- Alternaria solaniの菌体外β-1,3-グルカナーゼの多様性 : カビのグリコシターゼI
- Physicochemical Properties and Antitumor Activities of Carboxymethylated Dericatives of Glucan From Sclerotinia sclerotiorum
- Antitumor Activity of an Immunomodulating Material extracted from a Fungus, Peziza vesiculosa
- 「薬学会論文誌をより良くするために」のパネルを読んで
- Examination of the Active Center of a (1→3)-β-D-Glucanase Preparation, Zymolyase
- Antitumor Activity and Structural Characterization of a (1→3)-β-D-Glucan Extracted with Cold Alkali from Sclerotia of Sclerotinia sclerotiorum IFO 9395
- Physicochemical Properties and Immunomodulating Activities of Hot Water Extract from Sclerotia of Sclerotinia sclerotiorum IFO 9395(Biological)
- Structure and Antitumor Activity of a β-1,3-Glucan Isolated from the Culture Filtrate of Sclerotinia sclerotiorum IFO 9395
- Carbon-13 Nuclear Magnetic Resonance Spectroscopy of Various Yeasts as Aqueous Suspensions
- Generation of Cytotoxic Material to Murine Spleen Cells by Periodate Oxidation and Borohydride Reduction of Pectic Substances
- 肺炎球菌細胞壁中に存在する, リゾチーム消化抵抗性因子
- 6位分岐型β- (1→3) -グルカンの構造研究
- Fungal Glycosidases. V. Purification and Properties of an Extracellular exo-(1→3)-β-D-Glucosidase from Trichophyton mentagrophytes
- Polysaccharides of Type XIX Pneumococcus. III. Chemical Structure of the Repeating Unit
- Chemical Structure of an Intracellular Polysaccharide of Penicillium chrysogenum : Studies on Fungal Polysaccharides. VI.