Relationship between the Tissue Distribution and Antitumor Activity of Highly Branched (1→3)-β-D-Glucan, SSG
スポンサーリンク
概要
- 論文の詳細を見る
Distribution of ^3H-labeled (1→3)-β-D-glucan([^3H]SSG) obtained from the culture filtrate of Sclerotinia sclerotiorum IFO 9395,in various tissues in tumor-bearing mice was examined. [^3H]SSG administered intra-peritoneally was mainly detected in liver, spleen, kidney and tumor masses. In contrast to i.p. administration, intra-lesionally administered [^3H]SSG was not released from the tumor. Similarly, in a double grafted tumor system, [^3H]SSG was located in the administered tumor and not distributed in the distant site tumor, in spite of the fact that significant antitumor effect was shown in both tumor sites in this system. Winn assay confirmed the activation of the systemic antitumor immunity. These results suggested that the distribution of glucans would be one important factor in determining their antitumor effects. However, this would not always be necessary if systemic immunity could be induced.
- 社団法人日本薬学会の論文
- 1994-01-15
著者
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大野 尚仁
東京薬科大学薬学部免疫学教室
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須田 昌宏
Tokyo University Of Pharmacy And Life Science (formerly Tokyo College Of Pharmacy)
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須田 昌宏
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Scienc
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大野 尚仁
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Scienc
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安達 禎之
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Scienc
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宿前 利郎
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Scienc
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宿前 利郎
東京薬科大学 薬 免疫
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宿前 利郎
東京薬科大学
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安達 禎之
東京薬科大学免疫学
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大野 尚仁
東京薬科大学免疫学
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大野 尚仁
帝京大学 医学部微生物学講座
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安達 禎之
Laboratory Of Immunopharmacology Of Microbial Products Tokyo College Of Pharmacy
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Ohno N
Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of
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Adachi Yoshiyuki
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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