Inhibition of Expeirmental Pulmonary Metastasis of Lewis Lung Carcinoma by Orally Administered β-Glucan in Mice
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概要
- 論文の詳細を見る
The inhibitory effect on experimental pulmonary metastasis of Lewis lung carcinoma (3LL) of SSG, a (1→3)-β-D-glucan obtained from the fngus Sclerotinia sclerotirum IFO 9395,administered orally was examined in mice. Oral administration of SSG or 10 consecutive days just after the intravenous implantation of tumor cells significantly inhibited the experimental pulmonary metastasis of 3LL at a dose of 2000 μg. However, SSG administered orally involving other timings was less effective. In comparison with oral administration, SSG was effective when administered intraperitoneally for 10 consecutive days at a dose of 200 μg.These results suggest that SSG given by botn parental and nonparenteral routes is effective in the inhibition of experimental pulmonary metastasis of tumors.
- 社団法人日本薬学会の論文
- 1991-06-25
著者
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宿前 利郎
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
東京薬科大学 薬 免疫
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宿前 利郎
東京薬科大学
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櫻井 照明
Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy
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櫻井 照明
Laboratory Of Immunopharmacology Of Microbial Products Tokyo College Of Pharmacy
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桜井 照明
東京薬科大学 第1微生物
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橋本 幸一
Tokyo College Of Pharmacy
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及川 昭蔵
Nippon Beet Sugar Mfg. Co. Ltd.
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鈴木 巌
Tokyo College of Pharmacy
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櫻井 照明
Tokyo College of Pharmacy
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増田 昭芳
Nippon Beet Sugar Mfg., Co., Ltd.
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大沢 真澄
Nippon Beet Sugar Mfg., Co., Ltd.
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鈴木 巖
Tokyo College of Pharmacy
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大沢 真澄
Nippon Beet Sugar Mfg. Co. Ltd.
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増田 昭芳
Nippon Beet Sugar Mfg. Co. Ltd.
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