Effect of Glucans on the Antitumor Activity of Grifolan

概要

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The effects of antitumor-active [β-1,3-glucan (grifolan)] and inactive [β-1,6(islandican), α-1,4-(starch)]glucans in mice were compared. β-1,6-Glucan enhanced the antitumor activity of grifolan, whereas α-1,4-glucan showed a suppressive effect on the antitumor activity of grifolan. When these glucans were injected i.p. into normal mice, the glucans disappeared gradually. The rate of disappearance was in the order α-1,4>β-1,6>β-1,3. Grifolan induced peritoneal exudate cells, but β-1,6 and α-1,4-glucans did not. Only α-1,4-glucan was degradated by the lysate of the peritoneal exudate cells. These results indicate that the antitumor activity of β-1,3-glucan can be positively or negatively modulated by other glucans, and that glucans showing different antitumor effects have a variety of actions and fates in mice.
社団法人日本薬学会の論文
1986-05-25