Antitumor Activity and Structural Characterization of a (1→3)-β-D-Glucan Extracted with Cold Alkali from Sclerotia of Sclerotinia sclerotiorum IFO 9395
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概要
- 論文の詳細を見る
An antitumor (1→3)-β-D-glucan (TS-CAG III) was purified from the cold aqueous sodium hydroxide extract of the residue of hot water extract of sclerotia of Sclerotinia sclerotiorum IFO 9395 by sequential use of ion exchange chromatography on diethylaminoethyl Sephadex A-25,ethanol precipitation, and gel filtration on Sepharose CL-2B. TS-CAG III showed [α]_D-18°(0.4 N NaOH). From the results of methylation analysis and carbon-13 nuclear magnetic resonance spectroscopy, TS-CAG III was concluded to be a (1→3)-β-D-glucan bronched at position 6 of two in every five main chain glucosyl units. TS-CAG III formed a complex with Congo Red in dilute alkali solution, and showed potent antitumor activity against the solid form of sarcoma 180 in ICR mice.
- 公益社団法人日本薬学会の論文
- 1988-02-25
著者
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大野 尚仁
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
東京薬科大学
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大野 尚仁
東京薬科大学免疫学
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大野 尚仁
帝京大学 医学部微生物学講座
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篠原 久実
Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy
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篠原 久実
Tokyo College of Pharmacy
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Ohno N
Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of
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篠原 久実
Laboratory Of Immunopharmacology Of Microbial Products Tokyo College Of Pharmacy
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