Solubilization of Limulus Test Reactive Material(s) from Candida Cells by Murine Phagocytes
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概要
- 論文の詳細を見る
Solubilization of limulus test reactive materials from Candida was examined in the presence or absence of phagocytic cells. Solubilized limulus test reactive materials (LTRM) were detected in culture supernatant, and hot water and sodium hydroxide extracts of the acetone dried cells of Candida parapsilosis. Suspensions of Candida cells also reacted with limulus test, and LTRM were released from the acetone dried cells by serum treatment. After treatment of the acetone dried cells with polymorphonuclear leucocytes (PMN) or macrophages (Mφ), a significant amount of LTRM was solubilized. Significant amounts of LTRM were also released by PMN during treatment of live and growing C. parapsilosis. The reactivity of LTRM was completely inhibited by the addition of excess amount of purified (1→3)-β-D-glucan, suggesting LTRM from Candida cells as described above would contain (1→3)-β-D-glucan. These results suggested that LTRM during fungal infection would come from the extracellular water soluble polysaccharide fraction as well as the insoluble cell wall fraction solubilized by the action of phagocytes.
- 社団法人日本薬学会の論文
- 1992-06-25
著者
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宿前 利郎
東京薬科大学 薬 免疫
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宿前 利郎
東京薬科大学
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大野 尚仁
Lab. Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, School
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宿前 利郎
Lab. Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, School
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柴田 有康
Tokyo Research Institute, Seikagaku Corporation
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明田川 純
生化学工業株式会社
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大野 尚仁
東京薬科大学免疫学
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大野 尚仁
帝京大学 医学部微生物学講座
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南祇 典子
Lab. Immunopharmacology of Microbial Products, Tokyo College of Pharmacy
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田中 重則
Department of Applied Biochemistry, Tokyo Research Institute, Seikagaku Corporation
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明田川 純
Department of Applied Biochemistry, Tokyo Research Institute, Seikagaku Corporation
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柴田 有康
Department of Applied Biochemistry, Tokyo Research Institute, Seikagaku Corporation
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田中 重則
生化学工業中央研究所
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田中 重則
Department Of Applied Biochemistry Tokyo Research Institute Seikagaku Corporation
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Ohno N
Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of
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Nagi-miura Noriko
東京薬科大学 薬学部免疫学
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柴田 有康
Tokyo Research Institute Seikagaku Corporation
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南祇 典子
Laboratory Of Immunopharmacology Of Microbial Products Tokyo College Of Pharmacy
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