Preparation and Antitumor Activity of Hydroxyethylated Derivatives of 6-Branched (1→3)-β-D-Glucan, SSG, Obtained from the Culture Filtrate of Sclerotinia sclerotiorum IFO 9395
スポンサーリンク
概要
- 論文の詳細を見る
SSG is an antitumor branched (1→3)-β-D-glucan obtained from the culture filtrate of Sclerotinia sclerotiorum IFO 9395. Hydroxyethylation of SSG higher than MS 0.45 (MS value represents molar ratio of hydroxyethyl group vs. glucosyl group) by ethyleneoxide in aqueous sodium hydroxide lose the antitumor activity. Degradation of branching point of hydroxyethylated SSG (HE-SSG) by the sequential treatments of periodate oxidation, borohydride reduction, and mild acid hydrolysis of these derivatives regenerated the antitumor activity. These results directly demonstrated that the branching point covered, at least a part of, the dormant active site of SSG.
- 社団法人日本薬学会の論文
- 1990-09-25
著者
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宿前 利郎
東京薬科大学 薬 免疫
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宿前 利郎
東京薬科大学
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大野 尚仁
Lab. Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, School
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倉知 一也
Lab. Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, School
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宿前 利郎
Lab. Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, School
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大野 尚仁
東京薬科大学免疫学
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大野 尚仁
帝京大学 医学部微生物学講座
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Ohno N
Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of
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倉知 一也
Lab. Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Science School O
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