Dissociation of a Glucan Fraction (CO-1) from Protein-Bound Polysaccharide of Cordyceps ophioglossoides and Analysis of Its Antitumor Effect
スポンサーリンク
概要
- 論文の詳細を見る
A glucan moiety (CO-1) was dissociated from the antitumor protein-bound polysaccharide (SN-C) obtained from the culture of Cordyceps ophioglossoides by ultrasonication and heat treatment. CO-1 exhibited antitumor activity against murine sarcoma 180 when given by oral administration. CO-1 was also effective against syngeneic MM46 mammary carcinoma (solid form), but did not show any effect on ascitic tumors such as P388 leukemia. On intraperitoneal administration to normal mice, CO-1 increased the number of peritoneal exudate cells and strongly enhanced the chemiluminescence response of these exudate cells. The activity of CO-1 was higher than that of zymosan-A.
- 社団法人日本薬学会の論文
- 1988-11-25
著者
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宿前 利郎
東京薬科大学 薬 免疫
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宿前 利郎
東京薬科大学
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野本 亀久雄
Department Of Immunology Medical Institute For Bioregulation Kyushu University
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大森 俊弘
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.,
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田村 幸資
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.,
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若生 明徳
Research Institute of Life Science, Snow Brand Milk Products. Co., Ltd.,
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川西 悟生
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.,
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鶴 純明
Department of Bacteriology, National Defence Medical College
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宿前 利郎
Department of Microbial Chemistry, Tokyo College of Pharmacy
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大森 俊弘
雪印乳業(株)生物科学研究所
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川西 悟生
雪印乳業(株)生物科学研究所
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鶴 純明
Department Of Bacteriology National Defence Medical College
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田村 幸資
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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若生 明徳
Research Institute Of Life Science Snow Brand Milk Products. Co. Ltd.
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川西 悟生
雪印乳業 生物科学研
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