Isolation of Galactosaminoglycan Moiety (CO-N) from Protein-Bound Polysaccharide of Cordyceps ophioglossoides and Its Effects against Murine Tumors
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概要
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A galactosaminoglycan moiety was obtained from an antitumor polysaccharide fraction (SN-C) isolated from Cordyceps ophioglossoides culture. SN-C was subjected to sonication, then a protein-bound galactosaminoglycan (CO-N) was isolated specifically by precipitation with 10% ammonium hydroxide.When given intraperitoneally to mice, CO-N inhibited the proliferation of sarcoma 180 cells inoculated into the peritoneal cavity and exhibited a marked life-prolonging effect against ascitic tumors such as Ehrlich carcinoma and IMC carcinoma. CO-N also showed an inhibitory effect against solid Ehrlich carcinoma when given intratumorally and significantly inhibited the growth of a syngeneic solid tumor (MM46 mammary carcinoma) upon intravenous administration at a low dose.CO-N showed a cytocidal effect against cultured cells of IMC and P388D_1 in vitro. Flow cytometric analysis demonstrated that fluorescein isothiocyanate-CO-N binds to the surface of Ehrlich cells.
- 社団法人日本薬学会の論文
- 1989-04-25
著者
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光山 正雄
九大細菌
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宮崎 利夫
Tokyo College of Pharmacy
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野本 亀久雄
Department Of Immunology Medical Institute For Bioregulation Kyushu University
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大森 俊弘
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.,
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田村 幸資
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.,
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川西 悟生
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.,
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大森 俊弘
雪印乳業(株)生物科学研究所
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川西 悟生
雪印乳業(株)生物科学研究所
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福井 健司
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.,
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光山 正雄
Department of Bacteriology, School of Medicine, Niigata University
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宮崎 利夫
Japan, and Tokyo College of Pharmacy
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福井 健司
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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川西 悟生
雪印乳業 生物科研
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田村 幸資
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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川西 悟生
雪印乳業 生物科学研
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