Component Analysis of Protein-Bound Polysaccharide (SN-C) from Cordyceps ophioglossoides and Its Effects on Syngeneic Murine Tumors

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A protein-bound polysaccharide (SN-C) obtained from the culture filtrate of Cordyceps ophioglossoides, which has been reported to have antitumor acitivity, was analyzed for sugar and amino acid components. Gas chromatography revealed that the neutral sugar component of SN-C was mainly composed of glucose. By using an amino acid auto analyzer, it was shown that SN-C was composed of galactosamine as the sole aminosugar. An intraperitoneal administration of SN-C into mice inoculated intraperitoneally with syngeneic murine tumors such as MM46 mammary carcinoma or L5178Y leukemia suppressed the tumor growth and resulted in a significant prolongation of the life span. When used in vitro, SN-C significantly inhibited the proliferation of various murine tumor cells including P388. Futhermore, SN-C inhibited the incorporation of glucose into Meth-A tumor cells with a consequent decrease of deoxyribonucleic acid (DNA) synthesis. SN-C may be a new type of antitumor polysaccharide since this material seems to posess both direct antitumor effect and stimulating activity on the host-mediated effect.
公益社団法人日本薬学会の論文
1988-11-25