Structure and Antitumor Activity of the Less-Branched Derivatives of an Alkali-Soluble Glucan Isolated from Omphalia lapidescens. (Studies on Fungal Polysaccharide. XXXVIII)
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概要
- 論文の詳細を見る
The structure and antitumor activity of Smith-type digradation products (OL-2-I, OL-2-II and OL-2-III) of an alkali-soluble glucan, OL-2,isolated from a crude fungal drug "Leiwan" (Omphalia lapidescens) were investigated.Methylation analysis suggested that OL-2-I was a (1→3)-β-D-glucan with approximately one branch at every three main chain glucosyl units at each C-6 position; OL-2-II was a (1→3)-β-D-glucan with approximately one branch at two main chain glucosyl units at each C-6 position, and OL-2-III was a (1→3)-β-D-glucan with approximately one branch at twenty four main chain glucosyl units at each C-6 position (number of all main chain glucosyl units is on average). OL-2-I, OL-2-II and OL-2-III whic were Smith-type digradation products of OL-2,showed potent antitumor activity against the solid form of sarcoma 180 in ICR mice. These results indicated that the degree of β-linked branching at position 6 was remarkably related to the atitumor activity.
- 社団法人日本薬学会の論文
- 1992-01-25
著者
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斉藤 和夫
東京都健康安全研究センター
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大野 尚仁
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
東京薬科大学 薬 免疫
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宿前 利郎
東京薬科大学
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宮崎 利夫
Tokyo College of Pharmacy
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斉藤 和夫
The Tokyo Metropolitan Research Laboratory of Public Health
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西島 基弘
東京都立衛生研究所
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大野 尚仁
東京薬科大学免疫学
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大野 尚仁
帝京大学 医学部微生物学講座
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西島 基弘
The Tokyo Metropolitan Research Laboratory of Public Health
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Ohno N
Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of
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宮崎 利夫
Tokyo University Of Pharmacy And Life Science (formerly Tokyo College Of Pharmacy)
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宮崎 利夫
東京薬科大学 薬
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三浦 敏秀
Tokyo University Of Pharmacy And Life Science (formerly Tokyo College Of Pharmacy) Kitasato Universi
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