Chemical Characterization of a Fungal B-Cell Mitogen Obtained from the Fruit Body of Peziza vesiculosa
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概要
- 論文の詳細を見る
The chemical properties of a fungal B-cell mitogen obtained from the fruit body of Peziza vesiculosa were investigated. The non-dialyzable fraction (vesiculogen) of the hot water extract of P.vesiculosa was separated into mitogenic and non-mitogenic fractions by ammonium sulfate fractionation. The mitogenic fraction (precipitated at 20 to 60% ammonium sulfate) was composed of 75-80% protein and 17-19% carbohydrates. The mitogenic fraction was separated into 4 representative fractions by diethylaminoethyl-Sephadex A-25 and hydroxyapatite chromatographies, sequentially. In Sepharose CL-2B chromatography, all of the fractions showed wide ranges of molecular weight distribution. All of these representative fractions from Sepharose CL-2B were similar in amino acid compositions (rich in Ser, Glu, Gly, and Ala). These findings suggest that the mitogen is a high-molecular-weight, acidic polypeptide, showing charge and molecular weight heterogeneities.
- 1986-05-25
著者
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大野 尚仁
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
東京薬科大学
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大野 尚仁
東京薬科大学免疫学
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大野 尚仁
帝京大学 医学部微生物学講座
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鈴木 巌
Tokyo College of Pharmacy
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鈴木 巖
Tokyo College of Pharmacy
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Ohno N
Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of
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三村 博英
Tokyo College of Pharmacy
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