Generation of Cytotoxic Material to Murine Spleen Cells by Periodate Oxidation and Borohydride Reduction of Pectic Substances
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概要
- 論文の詳細を見る
Periodate oxidation-borohydride reduction (IO_4/BH_4) is a quite general modification method in carbohydrate chemistry to elucidate structure and function. Upon IO_4/BH_4 treatment, pectins from citrus and apple and pectic acid gave macromolecular modification products that were cytotoxic to spleen cells in vitro. On the other hand, the same treatment of a neutral polysaccharide, dextran, produced no cytotoxicity. These findings suggest that when active sites of carbohydrates are determined based on the results of these treatments, careful interpretation is necessary.
- 公益社団法人日本薬学会の論文
- 1985-08-25
著者
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大野 尚仁
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
東京薬科大学
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大野 尚仁
東京薬科大学免疫学
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鈴木 巖
Tokyo College of Pharmacy
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Ohno N
Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of
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橋本 好和
Tokyo College Of Pharmacy
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