Generation of Cytotoxic Material to Murine Spleen Cells by Periodate Oxidation and Borohydride Reduction of Pectic Substances

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概要

• 論文の詳細を見る

• Periodate oxidation-borohydride reduction (IO_4/BH_4) is a quite general modification method in carbohydrate chemistry to elucidate structure and function. Upon IO_4/BH_4 treatment, pectins from citrus and apple and pectic acid gave macromolecular modification products that were cytotoxic to spleen cells in vitro. On the other hand, the same treatment of a neutral polysaccharide, dextran, produced no cytotoxicity. These findings suggest that when active sites of carbohydrates are determined based on the results of these treatments, careful interpretation is necessary.

• 公益社団法人日本薬学会の論文
• 1985-08-25

著者

• 大野 尚仁

  Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)

• 宿前 利郎

  Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)

• 宿前 利郎

  東京薬科大学

• 大野 尚仁

  東京薬科大学免疫学

• 鈴木 巖

  Tokyo College of Pharmacy

• Ohno N

  Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of

• 橋本 好和

  Tokyo College Of Pharmacy

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