Neutral and Acidic Antitumor Polysaccharides Extracted from Cultured Fruit Bodies of Grifola frondosa
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概要
- 論文の詳細を見る
Water-soluble glucan fractions extracted from the cultured fruit bodies of Grifola frondosa with hot water, and with cold and hot sodium hydroxide containing urea showed potent antitumor activity in mice (Ohno et al., Chem. Pharm. Bull., 32,1142 (1984)). Each fraction was separated into neutral and acidic glucan fractions on a DEAE-Sephadex A-25 (HCO_3^-) column. Both neutral and acidic fractions showed potent antitumor activity against Sarcoma 180 solid tumor in ICR mice. From the results of methylation analysis and carbon-13 nuclear magnetic resonance spectroscopy, the neutral fractions contained mainly α-1,4 and 6-branched β-1,3 linkages, and the acidic fractions contained mainly β-1,6-and 6-branched β-1,3 linkages. The branching ratio was similar in both glucans. By colorimetric analysis, each acidic fraction was found to contain about 2-5% uronic acid. These findings indicated that the cultured fruit bodies of Grifola frondosa contain neutral and acidic antitumor glucans.
- 社団法人日本薬学会の論文
- 1985-03-25
著者
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宿前 利郎
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
東京薬科大学
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佐藤 吉朗
Nippon Beet Sugar Mfg. Co. Ltd.
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大野 尚仁
東京薬科大学免疫学
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及川 昭蔵
Nippon Beet Sugar Mfg. Co. Ltd.
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鈴木 巌
Tokyo College of Pharmacy
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鈴木 巖
Tokyo College of Pharmacy
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飯野 一義
Tokyo College of Pharmacy
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Ohno N
Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of
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宮崎 利夫
Tokyo University Of Pharmacy And Life Science (formerly Tokyo College Of Pharmacy)
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宮崎 利夫
東京薬科大学 薬
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三浦 敏秀
Tokyo University Of Pharmacy And Life Science (formerly Tokyo College Of Pharmacy) Kitasato Universi
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