Antitumor and Immunomodulating Activities of a β-Glucan Obtained from Liquid-Cultured Grifola frondosa
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概要
- 論文の詳細を見る
The effects of the β-1,3-glucan, LELFD, obtained from liquid-cultured mycelium of Grifola frondosa, on the growth of syngenetic tumors and immune responses in mice were examined. In Meth A or IMC solid tumor systems, LELFD administered intraperitoneally (i.p.) or intralesionally (i.l.) exhibited significant antitumor effects. However, the growth of L1210 and P388 leukemias was unaffected by the injection of LELFD.The injection of LELFD i.p. enhanced the activities of natural killer cells and macrophages in mice. LELFD also enhanced the antibody response when it was injected i.p. with sheep red blood cells into mice. Furthermore, it was found that LELFD could activate the alternative complement pathway.
- 社団法人日本薬学会の論文
- 1989-02-25
著者
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宿前 利郎
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
東京薬科大学 薬 免疫
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宿前 利郎
東京薬科大学
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佐藤 吉朗
Nippon Beet Sugar Mfg. Co. Ltd.
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橋本 幸一
Tokyo College Of Pharmacy
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及川 昭蔵
Nippon Beet Sugar Mfg. Co. Ltd.
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鈴木 巌
Tokyo College of Pharmacy
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大沢 真澄
Nippon Beet Sugar Mfg., Co., Ltd.
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鈴木 巖
Tokyo College of Pharmacy
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大沢 真澄
Nippon Beet Sugar Mfg. Co. Ltd.
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