Antitumor Activity and Structural Characterization of Polysaccharide Fractions Extracted with Cold Alkali from a Fungus, Peziza vesiculosa
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概要
- 論文の詳細を見る
Polysaccharides in the fruit body of Peziza vesiculosa were extracted with cold aqueous sodium hydroxide. The antitumor effect and structural features of the extracted fractions were examined. The above extraction gave a water-soluble heteroglycan fraction and a water-insoluble glucan fraction. The structural characteristics of these polysaccharides were estimated from the results of methylation analysis and ^<13>C-nuclear magnetic resonance spectroscopy. The heteroglycan fraction was composed of glucose and mannose (20 : 1). The fraction contained a large amount of β-1,3-glucosidic linkages (about 64%) and a small amount of α-1,4-glucosidic linkages (about 30%). Some of the β-1,3-linked glucose residues included branching points. The water-insoluble fraction contained a large amount of β-1,3-linkages (about 90%). Both fractions showed potent antitumor activity against the solid form of sarcoma 180 tumor in ICR mice.
- 1985-06-25
著者
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大野 尚仁
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
東京薬科大学
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大野 尚仁
東京薬科大学免疫学
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鈴木 巌
Tokyo College of Pharmacy
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鈴木 巖
Tokyo College of Pharmacy
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Ohno N
Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of
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三村 博英
Tokyo College of Pharmacy
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