Macrophage Activation in Vitro by Chemically Cross-Linked (1→3)-β-D-Glucans
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概要
- 論文の詳細を見る
The chemical cross-linking of soluble (1→3)-β-D-glucans having molecular weights of 21000 (CL 3h) and 6400 (CL 6h), and laminarin (CL LAMI), which showed negligible biological activity, by epichlorohydrin provided rigid particles. These particles showed no gel-to-sol transition upon the addition of sodium hydroxide. We compared the effects of chemical cross-linking on the biological activities of glucans. The alternative complement pathway was not activated by any of the cross-linked glucans. Glucose consumption, lysosomal enzyme release, and interleukin-1 production by mouse resident peritoneal macrophages incubated in vitro were strongly induced by CL 3h, CL 6h and CL LAMI. However, cross-linked dextran, Sephadex, did not exhibit any of these biological activities. These results suggested that chemical cross-linking of (1→3)-β-D-glucans enhances macrophage activities without opsonization by complement components.
- 社団法人日本薬学会の論文
- 1990-04-25
著者
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大野 尚仁
東京薬科大学薬学部免疫学教室
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大野 尚仁
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy)
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宿前 利郎
東京薬科大学 薬 免疫
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宿前 利郎
東京薬科大学
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安達 禎之
Tokyo College of Pharmacy
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安達 禎之
東京薬科大学免疫学
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大野 尚仁
東京薬科大学免疫学
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大野 尚仁
帝京大学 医学部微生物学講座
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及川 昭蔵
Nippon Beet Sugar Mfg. Co. Ltd.
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大沢 真澄
Nippon Beet Sugar Mfg., Co., Ltd.
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Ohno N
Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of
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Adachi Y
Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of
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大沢 真澄
Nippon Beet Sugar Mfg. Co. Ltd.
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Adachi Yoshiyuki
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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