Modulation of the Antitumor Effect and Tissue Distribution of Highly Branched (1→3)-β-D-Glucan, SSG, by Carrageenan
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概要
- 論文の詳細を見る
The action of carrageenan (CAR), a representative blocking reagent for phagocytes, on the antitumor effect and tissue distribution of highly branched (1→3)-β-D-glucan, SSG, was examined. CAR inhibited the antitumor effect of intraperitoneally administered SSG only when applied before inoculation of the tumor, and had little effect when applied after tumor inoculation. A similar result was observed when SSG was administered intralesionally. In contrast, CAR had considerable effect on tissue distribution of i.p. SSG. The differences with respect to the results in normal mice were : 1) the distribution of SSG from the peritoneal cavity to the rest of the body was inhibited, 2) large numbers of peritoneal exudate cells (PEC) were produced and a relatively high concentration of ^3H-SSG was found in the PEC fraction 48 h after administration of ^3H-SSG, 3) one week after administration, ^3H-SSG was distributed to throughout the body but the amount of ^3H-SSG distributed was lower than in normal mice, 4) a significant amount of ^3H-SSG was recovered from ligaments (containing omental milky spots, peritoneum, mesentery and associated fat) in which negligible amounts were found in normal mice. These results suggest that the inhibition of the antitumor effect of SSG by CAR probably results from the prevention of the natural resistance of mice which is related to phagocytic function, and that the distribution of SSG to throughout the body is significantly modulated by CAR.
- 社団法人日本薬学会の論文
- 1995-05-15
著者
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大野 尚仁
東京薬科大学薬学部免疫学教室
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須田 昌宏
Tokyo University Of Pharmacy And Life Science (formerly Tokyo College Of Pharmacy)
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須田 昌宏
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Scienc
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大野 尚仁
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Scienc
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安達 禎之
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Scienc
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宿前 利郎
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Scienc
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宿前 利郎
東京薬科大学 薬 免疫
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宿前 利郎
東京薬科大学
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安達 禎之
東京薬科大学免疫学
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大野 尚仁
東京薬大免疫
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大野 尚仁
東京薬科大学免疫学
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大野 尚仁
帝京大学 医学部微生物学講座
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大野 尚仁
東京薬科大学薬学部第一微生物学教室
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安達 禎之
Laboratory Of Immunopharmacology Of Microbial Products Tokyo College Of Pharmacy
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Ohno N
Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of
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