Activation of Complement and Limulus Coagulation Systems by an Alkali-Soluble Glucan Isolated from Omphalia lapidescens and Its Less-Branched Derivatives. (Studies on Fungal Polysaccharide. XXXIX)
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概要
- 論文の詳細を見る
Activation of the alternative pathway of complement (APC) and the Limulus factor G cascede by an alkali-soluble glucan, OL-2,isolated from a crude drug "leiwan" (Omphalia lapidescens) and its Smith-type degradation products were examined using human whole complement and Limulus lysate. OL-2 is a (1→3)-β-D-glucan having two branches at every third main chain glucosyl unit at each C-6 position (degree of branching (DB) : 2/3), and DB of the derivatives used in this study were OL-2-I (1/3), OL-2-II (1/2), OL-2-III (1/24) and OR-OL-2c (no branch : 0/1). Activation of APC by these glucans was dependent on incubation time and concentraiton. Under optimal conditions, OL-2-I, OL-2-II and OL-2-III showed stronger activation of APC than did the origical OL-2,and OR-OL-2c showed relatively weak activity. The structure-activity relationship of the activation of the factor G cascade was similar to that of APC. Considering the fact that the less branched derivatives of OL-2 also showed significantly stronger antitumor activity than OL-2,too much branching would suppress the recognition of (1→3)-β-D-glucan by the host-self defecse mechanisms.
- 社団法人日本薬学会の論文
- 1992-05-25
著者
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斉藤 和夫
東京都健康安全研究センター
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大野 尚仁
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Scienc
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宿前 利郎
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Scienc
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宿前 利郎
東京薬科大学 薬 免疫
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宿前 利郎
東京薬科大学
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斉藤 和夫
The Tokyo Metropolitan Research Laboratory of Public Health
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南祇 典子
Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy
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西島 基弘
東京都立衛生研究所
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大野 尚仁
東京薬科大学免疫学
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大野 尚仁
帝京大学 医学部微生物学講座
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西島 基弘
The Tokyo Metropolitan Research Laboratory of Public Health
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宮崎 利夫
Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy
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Ohno N
Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of
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南祇 典子
Laboratory Of Immunopharmacology Of Microbial Products Tokyo College Of Pharmacy
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宮崎 利夫
Tokyo University Of Pharmacy And Life Science (formerly Tokyo College Of Pharmacy)
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宮崎 利夫
東京薬科大学 薬
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三浦 敏秀
Tokyo University Of Pharmacy And Life Science (formerly Tokyo College Of Pharmacy) Kitasato Universi
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