Signal Transduction Pathway on β-Glucans-Triggered Hydrogen Peroxide Production by Murine Peritoneal Macrophages in Vitro
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概要
- 論文の詳細を見る
It has been reported that the biological activities of several β-glucans vary due to differences in their physicochemical properties. In this study we investigated the ability of β-glucans to trigger H_2O_2 production and activate signaling pathway on peritoneal macrophages. The most effective β-glucan tested on H_2O_2 production was zymocel which was a particulate preparation from the yeast cell wall. In contrast, gel-forming β-glucans which are known as immunoenhancers did not trigger the H_2O_2 production by macrophages at all. To identify the related signaling pathway for the particulate β-glucans-triggered H_2O_2 production, several inhibitors were applied. Hydrogen peroxide production triggered with phorbol myristate acetate was inhibited by pretreatment of macrophages with H-7,a protein kinase C inhibitor. However, β-glucans-triggered H_2O_2 production was not affected by H-7. The results suggested that genistein-sensitive tyrosine kinase and bromophenacyl bromide-sensitive phospholipase A_2 participated in the particulate β-glucans-triggered H_2O_2 production, although the phagocytosis of particulate β-glucans was not inhibited by either reagents. In conclusion, gel-forming (1→3)-β-D-glucans-induced activation was not sufficient to trigger H_2O_2 on macrophages, and pathways for particulate β-glucans-triggered H_2O_2 production were regulated differently from those for phagocytosis of β-glucans.
- 公益社団法人日本薬学会の論文
- 1996-01-15
著者
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OHNO Naohito
Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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Ohno Naohito
東京薬科大学 免疫学
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Ohno Naohito
東京薬科大学 薬 微生物
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Ohno N
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Adachi Yoshiyuki
東京薬科大学 免疫学
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Adachi Y
Tokyo Univ. Pharmacy And Life Sci. Tokyo Jpn
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Adachi Yoshiyuki
Laboratory Far Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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YADOMAE Toshiro
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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Adachi Yoshiyuki
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Ohno Naohito
Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma
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Ohno Naohito
Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc
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OKAZAKI Mitsuhiro
Laboratory of Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Phar
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CHIBA Norihisa
Laboratory of Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Phar
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Yadomae T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Okazaki M
Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma
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Chiba Norihisa
Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma
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