Soy Isoflavone Aglycone Modulates A Hematopoietic Response in Combination with Soluble β-Glucan : SCG(Miscellaneous)
スポンサーリンク
概要
- 論文の詳細を見る
Soy isoflavone aglycones (IFAs) have a wide range of biological actions that suggest they may be of use in cancer prevention. On the other hand, a branched β-glucan from Sparassis crispa (SCG) is a major 6-branched 1, 3-β-D-glucan in an edible/medicinal mushroom : Sparassis crispa showing antitumor activity. We have previously reported that both oral and intraperitoneal administration of SCG enhanced the hematopoietic response in cyclophosphamide (CY)-induced leukopenic mice. In this study, we investigated the hematopoietic response due to IFA in combination with SCG in CY-induced leukopenic mice. The oral administration of IFA in combination with SCG synergistically enhanced the number of white blood cells, and increased spleen weight. Analyzing the leukocyte population by flow cytometry, the combination of IFA and SCG increased the number of monocytes and granulocytes in the spleen. Taken together, the combination of IFA and SCG synergistically provides the hematopoietic responses that are enhanced over IFA or SCG alone.
- 社団法人日本薬学会の論文
- 2005-12-01
著者
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中島 誠
北海道大学大学院薬学研究科
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中島 正晴
県立食品総合研究所
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OHNO Naohito
Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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Ohno Naohito
東京薬科大学 免疫学
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Ohno Naohito
東京薬科大学 薬 微生物
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Ohno Naohito
Lab. For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo Univ. Of Pharmacy And Lif
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Ohno N
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Adachi Yoshiyuki
東京薬科大学 免疫学
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Adachi Y
Tokyo Univ. Pharmacy And Life Sci. Tokyo Jpn
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Adachi Yoshiyuki
Laboratory Far Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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HARADA Toshie
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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NAKAJIMA Mitsuhiro
Minahealth Co., Ltd.
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YADOMAE Toshiro
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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MASUDA Susumu
Kikkoman Co.
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ARII Masayuki
Kikkoman Co.
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Adachi Yoshiyuki
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Ohno Naohito
Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma
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Ohno Naohito
Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc
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Suda M
Tokyo University Of Pharmacy And Life Science (formerly Tokyo College Of Pharmacy)
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Suda Masahiro
Kikkoman Co.
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Nakajima Mitsuhiro
Minahealth Co. Ltd.
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Harada Toshie
Seikagaku Corporation
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Yadomae T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Harada Toshie
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Ohno Naohito
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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