Architecture of Alkaline-soluble and Bioactive Polysaccharide from the Kernels of Prunus mume SIEB. et ZUCC. Assessed by Anti P-1 Antibody

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概要

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• P-1 was partially hydrolyzed with 0.01, 0.05, and 0.1 M trifluoroacetic acid (TFA), successively, and the dialyzable (E-1, E-2, and E-3) and non-dialyzable (I-1, I-2, and I-3) fractions were prepared and analyzed chemically and immunochemically. Either I-1 or E-1 reacted with anti P-1 serum as strongly as P-1 and were mitogenic. The cross-reactivity of I-2 and I-3 was less than I-1 with anti P-1 serum. However, they were as mitogenic as I-1. The cross-reactivity of E-2 and E-3 to anti P-1 serum was also very weak, and they were not mitogenic. The E-1 fraction had a similar sugar composition to I-1 and P-1. E-2 was a monosaccharide, all of Ara, and would be from the linkage of furanosyl residues in P-1. The composition of E-3 was free from Ara and the structure of E-3 was similar to that of I-3. E-3 would be considered to be deleted arabinofuranose from E-1. These results suggest that the mitogenic activity measured by the alkaline phosphatase assay is a property of the core part, I-3, but that P-1 contains several epitopes other than the core part by the immunochemical analysis.

• 社団法人日本農芸化学会の論文
• 1996-11-23

著者

• Ohno Naohito

  東京薬科大学 免疫学

• Ohno Naohito

  東京薬科大学 薬 微生物

• Ohno Naohito

  Lab. For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo Univ. Of Pharmacy And Lif

• Ohno N

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Ohno Naohito

  Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma

• Ohno Naohito

  Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc

• Ohno Naohito

  School Of Pharmacy Tokkyo University Of Pharmacy And Life Science

• DOGASAKI Chikaku

  Faculty of Environmental Health Science, Azabu University

• NISHIJIMA Motohiro

  Tokyo Metropolitan Research Laboratory of Public Health

• YADOMAE Toshiro

  School of Pharmacy, Tokyo University of Pharmacy and Life Science

• MIYAZAKI Toshio

  School of Pharmacy, Tokyo University of Pharmacy and Life Science

• NISHIJIMA Masahiro

  Department of Biochemistry and Cell Biology, National Institute of Health

• Miyazaki T

  Department Of Applied Microbiology Nippon Roche Research Center

• Miyazaki Toshio

  School Of Pharmacy Tokyo University Of Pharmacy And Life Science

• Nishijima Masahiro

  Department Of Biochemistry And Cell Biology National Institute Of Health

• Yadomae T

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Dogasaki C

  Azabu Univ. Kanagawa Jpn

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