Effects of Benzyl Glucoside and Chlorogenic Acid from Prunus mume on Adrenocorticotropic Hormone (ACTH) and Catecholamine Levels in Plasma of Experimental Menopausal Model Rats(Pharmacognosy)
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概要
- 論文の詳細を見る
To investigate the effectiveness of benzyl β-D-glucopyranoside (BG) and chlorogenic acid (CA), the constituents of the fruit of Primus mume, for relieving tension in experimental menopausal model rats (M-rats) caused by ether stress, the effects of BG and CA on adrenocorticotropic hormone (ACTH) and catecholamine (adrenaline, noradrenaline, and dopamine) levels were examined in the plasma of M-rats. Caffeic acid, quinic acid, and rosmarinic acid, which are compounds structurally related to CA, were also examined. BG obviously recovered catecholamine levels decreased by ether stress and increased dopamine to high levels. On the other hand, CA significantly decreased the ACTH level increased by ether stress and showed the greatest effect of all compounds. These results suggest that BG and CA may contribute to relieving the tension in M-rats caused by etherstress.
- 公益社団法人日本薬学会の論文
- 2004-01-01
著者
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Matsumoto Ken-ichi
Dep. Of Biosignaling And Radioisotope Experiment Center For Integrated Res. In Sci. Shimane Univ.
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Matsumoto Ken-ichiro
Departments Of Physical Chemistry Showa Pharmaceutical University
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MIYAZAKI Toshio
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Matsumoto K
Graduate School Of Bioresource And Bioenvironmental Sciences Kyushu Univ.
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Matsumoto K
Department Of Bioscience And Biotechnology Division Of Bioresource And Bioenvironmental Sciences Fac
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Yamada K
Graduate School Of Pharmaceutical Sciences Kyushu University
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Yamada Katsuya
Graduate School Of Pharmaceutical Sciences Nagoya City University
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INA Hiroji
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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YAMADA Kenji
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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MATSUMOTO Kosai
Umekenkyukai Foundation
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Ina H
Tokyo College Of Pharmacy
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Ina Hiroji
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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MATSUMOTO Ken-ichi
Denartment of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Miyazaki Toshio
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Yamada Kenji
Tokyo University Of Pharmacy And Life Sciences School Of Pharmacy
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