Effects of α_1-Acid Glycoprotein on Erythrocyte Deformability and Membrane Stabilization(Biopharmacy)
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概要
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The effects of α_1-acid glycoprotein (AGP) on human erythrocyte membrane were examined in vitro. Bovine and dog AGP, in addition to human AGP or asialo human AGP were used, and the collected data were compared with that for human serum albumin (HSA). A new technique developed by Kikuchi was used to investigate erythrocyte deformability. The addition of AGPs including human AGP facilitated the passage of human erythrocytes with an average diameter of 7.2μm suspended in phosphate buffered saline (PBS) through a 5 μm wide microchannel; hemolysis was suppressed after the passage. The stabilizing effects of AGPs on membrane were evaluated. Human AGP prevented hemolysis induced by hypotonic phosphate buffer solution. The effects of human AGP on the oxidative changes in erythrocytes exposed to oxygen radicals were investigated. Human AGP protected erythrocytes from H_2O_2 and prevented the oxidation of dihydrorhodamine 123 to rhodamine 123 from H_2O_2. We propose that the antioxidant activity of human AGP is due to the binding of free radicals. In all studies, the effects of human AGP on erythrocytes might not be a function of the negative charge associated with sialyl residues, because the presence of N-acetylneuraminic acid had no effect. However, human AGP may promote microcirculation and antioxidant activity compared with HSA. No species differences in the physiological function of AGP were found. These results suggest that an increase in the AGP content of serum above the normal value found under pathological conditions facilitates the passage of erythrocytes through capillaries, stabilizes erythrocyte membranes and protects against oxidative stress, all of which are favorable for microcirculation.
- 公益社団法人日本薬学会の論文
- 2003-01-01
著者
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IRIE Tetsumi
Faculty of Pharmaceutical Sciences, Kumamoto University
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Irie Tetsumi
Faculty Of Pharmaceutical Sciences Kumamoto University
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Matsumoto Ken-ichi
Dep. Of Biosignaling And Radioisotope Experiment Center For Integrated Res. In Sci. Shimane Univ.
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Matsumoto Ken-ichiro
Departments Of Physical Chemistry Showa Pharmaceutical University
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OTAGIRI MASAKI
Faculty of Pharmaceutical Science, Kumamoto University
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西 勝英
熊本大学医学薬学研究部生体機能薬理学教室
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Matsumoto K
Graduate School Of Bioresource And Bioenvironmental Sciences Kyushu Univ.
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SUENAGA Ayaka
Faculty of Pharmaceutical Science, Kumamoto University
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徳冨 芳子
Graduate School Of Medical Sciences Kumamoto University
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Matsumoto K
Department Of Bioscience And Biotechnology Division Of Bioresource And Bioenvironmental Sciences Fac
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Suenaga A
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Suenaga Ayaka
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Suenaga Ayaka
Faculty Of Pharmaceutical Science Kumamoto University
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Otagiri M
Graduate School Of Pharmaceutical Sciences Kumamoto University
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MATSUMOTO Kazuaki
Faculty of Pharmaceutical Sciences, Kumamoto University
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NISHI Katsuhide
School of Medicine, Kumamoto University
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TOKUTOMI Yoshiko
School of Medicine, Kumamoto University
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MATSUMOTO Ken-ichi
Denartment of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Otagiri M
Kumamoto Univ. Kumamoto Jpn
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Otagiri Masaki
Faculty Of Pharmaceutical Science Kumamoto University
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Nishi Katsuhide
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Kumamoto University
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