α_1-Acid Glycoprotein Suppresses Rat Acute Inflammatory Paw Edema through the Inhibition of Neutrophils Activation and Prostaglandin E_2 Generation(Pharmacology)

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概要

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• α_1Acid glycoprotein (AGP) is an acute phase protein. Whereas the expression of AGP in an inflammatory state is enhanced by inflammatory cytokines including interleukin-1, 6 (IL-1 and IL-6), and tumor necrosis factor-α (TNF-α), the biological significance of AGP remains unclear. In the current study, the anti-inflammatory effect of AGP on the acute inflammatory state was examined in vivo and in vitro. AGP suppressed carrageenan-, dextran- and kaolin-induced paw edema and vascular permeability in rat. These results suggest that both initia inflammatory mediators (serotonin and histamine) and later inflammatory mediators (prostaglandin and bradykinin) are involved in the anti-inflammatory effects of AGP. In fact, prostaglandin E_2 (PGE_2) generation in plasma was significantly inhibited by AGP. Moreover, AGP inhibited the migration of neutrophils treated with N-formyl-methionyl-leucyl-phenylalanine (fMLP) through membrane filter. In addition, AGP significantly suppressed superoxide generation from neutrophils that has been treated with fMLP or phorbol 12-myristate 13-acetate. These results imply that the anti-inflammatory effect of AGP may involve the inhibition of neutrophils migration. The data obtained in this study support a scenario in which an increase in AGP concentration in pathological conditions suppresses inflammation reactions induced by autacoids and neutrophils activities and that AGP plays an important role in the maintenance in the body.

• 公益社団法人日本薬学会の論文
• 2007-07-01

著者

• Matsumoto Ken-ichi

  Dep. Of Biosignaling And Radioisotope Experiment Center For Integrated Res. In Sci. Shimane Univ.

• Matsumoto Ken-ichiro

  Departments Of Physical Chemistry Showa Pharmaceutical University

• 西 勝英

  熊本大学医学薬学研究部生体機能薬理学教室

• Matsumoto K

  Graduate School Of Bioresource And Bioenvironmental Sciences Kyushu Univ.

• OTAGIRI Masaki

  Graduate School of Pharmaceutical Sciences, Kumamoto University

• Kadowaki Daisuke

  Graduate School Of Pharmaceutical Sciences Kumamoto University

• 徳冨 芳子

  Graduate School Of Medical Sciences Kumamoto University

• 徳冨 直史

  Graduate School Of Medical Sciences Kumamoto University

• Matsumoto K

  Department Of Bioscience And Biotechnology Division Of Bioresource And Bioenvironmental Sciences Fac

• Suenaga A

  Graduate School Of Pharmaceutical Sciences Kumamoto University

• Suenaga Ayaka

  Graduate School Of Pharmaceutical Sciences Kumamoto University

• Kikuchi Mari

  Graduate School Of Pharmaceutical Sciences Kumamoto University

• Otagiri M

  Graduate School Of Pharmaceutical Sciences Kumamoto University

• Otagiri Masaki

  Graduate School Of Pharmaceutical Sciences Kumamoto University

• MATSUMOTO Kazuaki

  Graduate School of Pharmaceutical Sciences, Kumamoto University

• NISHI Koji

  Graduate School of Pharmaceutical Sciences, Kumamoto University

• TOKUTOMI Yoshiko

  Graduate School of Medical Sciences, Kumamoto University

• TOKUTOMI Naofumi

  Graduate School of Medical Sciences, Kumamoto University

• NISHI Katsuhide

  Graduate School of Medical Sciences, Kumamoto University

• MATSUMOTO Ken-ichi

  Denartment of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University

• Otagiri M

  Kumamoto Univ. Kumamoto Jpn

• Nishi Katsuhide

  Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Kumamoto University

• Nishi Koji

  Graduate School of Information Science and Electrical Engineering, Kyushu University, Fukuoka 819-0395, Japan

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