Afferent Discharges in the Left Cardiac Sympathetic Nerve Induced by Asphyxia in the Cat

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In the lightly anesthetized cats, acute asphyxia alone did not produce any afferent discharges in the cardiac sympathetic nerve, while prolonged low ventilation provoked spontaneous afferent discharges and acute asphyxia combined with low ventilation increased the frequency of the impulses. Intravenous injection of epinephrine, acetylcholine and veratrine did not elicit afferent activities of the cardiac sympathetic nerve and also had no effect on the discharges caused by low ventilation. Intrapericardial injection of procaine abolished the afferent discharges in the nerve exerted by prolonged low ventilation. It seems that some metabolic factors produced by low ventilation would be responsible for the initiation of impulses at the afferent nerve endings of cardiac sympathetic innervation.
International Heart Journal刊行会の論文