An analysis of the depressant effect of indomethacin on contractions of isolated and perfused rat hearts.
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概要
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The depressant effect of indomethacin on contractions of isolated rat hearts was investigated under a constant heart rate. Ca<SUP>2+</SUP> produced dose-dependent increases in myocardial contractile force and coronary perfusion pressure. Indomethacin-infusion significantly decreased myocardial contractile force and depressed increases in myocardial contractile force by Ca<SUP>2+</SUP>, but never affected both coronary perfusion pressure and increases in coronary perfusion pressure by Ca<SUP>2+</SUP>. Results suggest that indomethacin will depress myocardial contractile force with no involvement of any calcium antagonism.
- 公益社団法人 日本薬理学会の論文
著者
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Nakasone Junko
Department Of Pharmacology School Of Medicine Faculty Of Medicine University Of The Ryukyus
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Takeo Satoshi
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy & Life Science
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Sakanashi Matao
Department Of Pharmacology And Department Of Pediatrics School Of Medicine University Of The Ryukyus
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NAGAMINE Fumio
Department of Pharmacology
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MIYAMOTO Yoshimasa
Tsumura Research Institute for Pharmacology
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KATO Takayuki
Tsumura Research Institute for Pharmacology
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SAKANASHI Matao
Department of Pharmacology, School of Medicine, Faculty of Medicin eUniversity of the Ryukyus
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NAGAMINE Fumio
Department of Pharmacology, School of Medicine, Faculty of Medicin eUniversity of the Ryukyus
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