Effects of Trandolapril on Cardiac Angiotensin I Converting Enzyme Activity in Rats with Chronic Heart Failure Following Myocardial Infarction
スポンサーリンク
概要
- 論文の詳細を見る
The effects of longterm treatment with a novel angiotensin I converting enzyme (ACE) inhibitor, trandolapril, on ACE activity and cardiac function in rats with chronic heart failure (CHF) were examined and compared with those of captopril and enalapril. Left coronary artery ligation of rats resulted in decreases in mean arterial pressure, left ventricular systolic pressure, dP/dt, cardiac output and stroke volume indices, and increases in left ventricular enddiastolic pressure and systemic vascular resistance 12 weeks after the operation. A significant increase in ACE activity of the myocardium, but not that of serum or other tissues, was detected in the CHF rat 12 weeks after the operation. Oral treatment with ACE inhibitors (10mg/kg/day captopril, 10mg/kg/day enalapril or 3mg/kg/day trandolapril) from the 2nd to 12th week, attenuated the changes in cardiac output and stroke volume indices, left ventricular enddiastolic pressure and systemic vascular resistance of the CHF rat. Treatment also attenuated the increase in the cardiac ACE activity of CHF rats. A close relationship between the decrease in cardiac output index and the increase in cardiac ACE activity was detected. The results suggest that trandolapril, like other ACE inhibitors, exerts a beneficial effect on cardiac function in the CHF rat and that one of the mechanisms for this effect is attenuation of elevated cardiac ACE activity.
著者
-
Takeo Satoshi
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy & Life Science
-
Sanbe Atsushi
Department Of Pharmacology National Research Institute For Child Health And Development
-
TSUKADA Junko
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
-
SANBE Atsushi
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
関連論文
- Possible Involvement of Mitochondrial Energy-Producing Ability in the Development of Right Ventricular Failure in Monocrotaline-Induced Pulmonary Hypertensive Rats
- Intravenous Injection of Neural Progenitor Cells Improves Cerebral Ischemia-Induced Learning Dysfunction
- Effects of a Novel Cyclohexane Dicarboximide Derivative, ST-6, on Reperfusion-Induced Arrhythmia in Rats
- The Effects of a Novel Cyclohexane Dicarboximide Derivative, ST-6,on Hypoxia/Reoxygenation Injury in Perfused Rat Heart
- Changes in Hsp60 Level of the Failing Heart Following Acute Myocardial Infarction and the Effect of Long-Term Treatment with Trandolapril(Pharmacology)
- β-Adrenoceptor Antagonistic Actions and Mutagenicities of R(+)- and S(-)-Enantiomers of N-Desisopropylpropranolol and Its N-Acetyl Conjugate
- Preferable Anesthetic Conditions for Echocardiographic Determination of Murine Cardiac Function
- Characterization of Microsphere Embolism-Induced Impairment of Learning and Memory Function and the Cholinergic System
- Alterations in Dystrophin-Related Glycoproteins in Development of Right Ventricular Failure in Rats
- Alterations in Pharmacological Action of the Right Ventricle of Monocrotaline-Induced Pulmonary Hypertensive Rats
- The Effects of Monobromobimane on Calcium and Phenylarsineoxide-Induced Mitochondrial Swelling and Cytochrome c Release in Isolated Brain Mitochondria (Pharmacology)
- Effects of Monochlorobimane on Cerebral Ischemia-Induced Damage to Mitochondria(Pharmacology)
- Effects of Nefiracetam on Cerebral Adenylyl Cyclase Activity in Rats with Microsphere Embolism-Induced Memory Dysfunction
- Effects of Nebracetam on Synaptosomal Monoamine Uptake of Striatal and Hippocampal Regions in Rats
- PHYSIOLOGICAL ROLES OF ALDO/KETO REDUCTASES IN REPRODUCTIVE ORGANS
- Effects of Aprindine on Ischeia/Reperfusion-Induced Cardic Contractile Dysfunction of Perfused Rat Heart
- -P165- PROTECTIVE EFFECT OF MEPACRINE AGAINST HYPOXIA-INDUCED DERANGEMENTS OF ISOLATED PERFUSED RAT HEART
- Involvement of Adenosine Receptor, Potassium Channel and Protein Kinase C in Hypoxic Preconditioning of Isolated Cardiomyocytes of Adult Rat
- Long-Term Supplementation With Eicosapentaenoic Acid Salvages Cardiomyocytes From Hypoxia/Reoxygenation-Induced Injury in Rats Fed With Fish-Oil-Deprived Diet
- Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system(CELL AND TISSUE ENGINEERING)
- CHARACTERIZATION OF PROPRANOLOL-INDUCED RELAXATION OF CORONARY ARTERY
- Comparison of Myocardial and Adipose Tissue Lipase Activity in the Rat
- Effects of 2-Nicotinamidoethyl Nitrate (SG-75, Nicorandil) on Indomethacin-Induced Contractions of Isolated Dog Coronary Arteries
- Effects of 4-Aminopyridine and Tetraethylammonium on Relaxant Responses of Isolated Dog Coronary Arteries to 2-Nicotinamidoethyl Nitrate (SG-75)
- Molecular Mechanisms of α-Crystallinopathy and Its Therapeutic Strategy
- Effects of Trandolapril on Cardiac Angiotensin I Converting Enzyme Activity in Rats with Chronic Heart Failure Following Myocardial Infarction
- In Vivo Profile of Myocardial Energy Metabolism of Pressure-overloaded Rat
- Hyperresponsiveness of Cardiac Muscles to Histamine in Reserpine-Treated Guinea Pigs.
- Possible Pathway of Na+ Flux into Mitochondria in Ischemic Heart
- Metabotropic Glutamate Receptor 5 Activation Enhances Tyrosine Phosphorylation of the N-methyl-D-aspartate (NMDA) Receptor and NMDA-Induced Cell Death in Hippocampal Cultured Neurons
- Sustained Changes in Acetylcholine and Amino Acid Contents of Brain Regions Following Microsphere Embolism in Rats.
- Changes in Small Heat Shock Proteins HSPB1, HSPB5 and HSPB8 in Mitochondria of the Failing Heart Following Myocardial Infarction in Rats
- Time course of changes in brain energy metabolism of the rat after microsphere-induced cerebral embolism.
- A Comparison of the Effects of Estradiol and 2- and 4-Hydroxyestradiol on Uterine Ornithine Decarboxylase Activity in Immature Rats.
- An analysis of the depressant effect of indomethacin on contractions of isolated and perfused rat hearts.
- Calcium accumulating ability of mitochondria from bovine coronary artery. Comparison with aortic mitochondria.
- Serotonin Suppresses β-Casein Expression via Inhibition of the Signal Transducer and Activator of Transcription 5 (STAT5) Protein Phosphorylation in Human Mammary Epithelial Cells MCF-12A