Effects of 2-Nicotinamidoethyl Nitrate (SG-75, Nicorandil) on Indomethacin-Induced Contractions of Isolated Dog Coronary Arteries

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Effects of 2-nicotinamidoethyl nitrate (SG-75) on contractile responses of dog coronary arteries to indomethacin were investigated in vitro. Indomethacin (3×10-8and 3×10-7Gm/ml) produced contractions of isolated coronary arterial strips, which were reproduced by successive administration of the drug. SG-75 (10-5Gm/ml) administered 5min prior to indomethacin, significantly depressed indomethacin-induced contractions of the strips. In coronary arterial strips under potassium-contracture, SG-75 10-8-10-4Gm/ml) produced concentration-dependent relaxations, which were not affected by prior administration of indomethacin (3×10-6Gm/ml). Tranylcypromine (10-4Gm/ml) did not influence the relaxant responses of the strips to SG-75 (10-8-10-5Gm/ml) but significantly depressed them to SG-75 (10-4Gm/ml). Results indicate that large doses of SG-75 will induce a relaxant effect on isolated dog coronary arteries through activation of intravascular biosynthesis or release of prostacyclin from vascular tissues.
International Heart Journal刊行会の論文