Regional Vascular Responses to Thromboxane A2 Analogue and Their Blockade with Vapiprost, a Selective Thromboxane Receptor Blocking Drug, in Anesthetized Dogs.
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概要
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Regional vascular responses to the thromboxane A<SUB>2</SUB> analogue U46619 and effects of the selective thromboxane receptor blocking drug vapiprost on these responses were examined in anesthetized dogs. Hemodynamic responses to U46619 (0.5 μg/kg into the left atrium), norepinephrine (NE, 0.3 μg/kg, i.v.) and angiotensin II (All, 30 or 60 ng/kg, i.v.) were periodically tested before and after administration of vapiprost (10, 30 or 100 μg/kg, i.v.) or its vehicle. In the absence of vapiprost, U46619 increased total peripheral (TPR), vertebral (VR), coronary (CR) and renal (RR) vascular resistance by 60.1 ± 4.7%, 33.6 ± 4.9%, 15.3 ± 1.3% and 120.8 ± 17.4%, respectively, indicating that vasoconstrictor responses to U46619 were most prominent in the renal vascular bed as compared to those in the vertebral or coronary vasculatures. Vapiprost as well as the vehicle did not affect the baseline hemodynamics. However, vapiprost apparently inhibited the U46619-induced vasoconstriction in all measured vascular beds in a dose-related manner without attenuating vasoconstrictor responses to NE and All, although significantly larger inhibition of U46619-induced increases in RR was observed as compared to the inhibitions of VR and CR. These results demonstrate that there was a regional difference both in the vasoconstrictor responses to U46619 and in the blocking effects of vapiprost, and indicate that vapiprost is a potent and selective antagonist for thromboxane receptors in vivo.
- 公益社団法人 日本薬理学会の論文
著者
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Noguchi Katsuhiko
Department Of Pharmacalogy School Of Medicine Faculty Of Medicine University Of The Ryukyus
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Sakanashi Matao
Department Of Pharmacology And Department Of Pediatrics School Of Medicine University Of The Ryukyus
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Matsuzaki Toshihiro
Department Of Pharmacology School Of Medicine Faculty Of Medicine University Of The Ryukyus
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CHIBANA Takao
Department of Pharmacology, School of Medicine, Faculty of Medicine, University of the Ryukyus
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OJIRI Yoshihiko
Laboratory of Physiology and Pharmacology, School of Health Sciences, Faculty of Medicine, University of the Ryukyus
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OJIRI Yoshihiko
Laboratory of Physiology and Pharmacology, School of Health Sciences
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