Depressant Effect of Trapidil on Dog Coronary Arterial Contraction Induced by Ergonovine
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概要
- 論文の詳細を見る
Effects of trapidil on ergonovine-induced contractions of isolated dog coronary arteries were investigated in vitro. Ergonovine produced dosedependent contractions of helical strips cut from the left circumflex branches of coronary arteries. Trapidil significantly depressed thesecontractions. 5-HT also produced dose-dependent contractions of the strips, which were depressed by trapidil. In isolated rabbit femoral arterial preparations, norepinephrine dose-dependently contracted the strips. Phentolamine significantly depressed these contractions, and trapidil depressed them when relatively high doses were applied previously. Results indicate that trapidil has a depressant effect on coronary arterial contractions induced by ergonovine, partly through antagonism to 5-HT receptor and/or adrenergic alpha receptor.
- International Heart Journal刊行会の論文
著者
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Sakanashi Matao
Department Of Pharmacology And Department Of Pediatrics School Of Medicine University Of The Ryukyus
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Yoshikawa Yushi
Department of Pharmacology, Kumamoto University Medical School
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YONEMURA Ken-ichi
Department of Physiology and Pharmacology, Kumamoto University Medical School
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KONDOH Genzo
Department of Pharmacology Kumamoto University Medical School
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YONEMURA Ken-ichi
Department of Physiology,Kumamoto University Medical School
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SAKANASHI Matao
Department of Pharmacology Kumamoto University Medical School
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YOSHIKAWA Yushi
Department of Pharmacology Kumamoto University Medical School
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