Glutathione S-transferases and chloroform toxicity in streptozotocin-induced diabetic rats.
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概要
- 論文の詳細を見る
The glutathione S-transferase activity in liver and kidney cytosol was significantly decreased in short term diabetes induced with streptozotocin, whereas no decrease in the transferase was observed in phenobarbital-treated diabetic rats. Toxicity of chloroform was potentiated in streptozotocin- or phenobarbital-treated rats. The decrease in liver cytosolic and microsomal glutathione S-transferase activity was observed in long term diabetic rats, and only microsomal transferase activity was restored by insulin treatment. There was no release of glutathione S-transferases into the serum in the diabetic rats, and the transferases were not inhibited by streptozotocin in vitro. These results showed that glutathione S-transferase activity decreased during diabetes, and this decrease may contribute to altering drug metabolism and toxicity in diabetes.
- 公益社団法人 日本薬理学会の論文
著者
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Aniya Yoko
Laboratory Of Functional And Molecular Pharmacology Graduate School Of Medicine University Of The Ry
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SAKANASHI Matao
Department of Pharmacology, School of Medicine, Faculty of Medicine, University of the Ryukyus
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Mimura Goro
Second Department Of Internal Medicine Ryukyu University
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Sakanashi Matao
Department Of Pharmacology And Department Of Pediatrics School Of Medicine University Of The Ryukyus
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OJIRI Yoshihiko
Laboratory of Physiology and Pharmacology, School of Health Sciences, Faculty of Medicine, University of the Ryukyus
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MURAKAMI Keiji
Second Department of Internal Medicine, School of Medicine, University of the Ryukyus
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SUNAGAWA Ryuji
Second Department of Internal Medicine, School of Medicine, Faculty of Medicine, University of the Ryukyus
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ZHENZHONG Guan
Second Department of Internal Medicine, School of Medicine, Faculty of Medicine, University of the Ryukyus
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OJIRI Yoshihiko
Laboratory of Physiology and Pharmacology, School of Health Sciences
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MURAKAMI Keiji
Second Department of Internal Medicine, School of Medicine, Faculty of Medicine, University of the Ryukyus
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