Effect of polyoxyethylene-modified superoxide dismutase on recovery of myocardial dysfunction after coronary stenosis in dogs.
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概要
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The effects of superoxide dismutase modified with polyoxyethylene (SOD-POE) on impairment of myocardial segment shortening (SS) during coronary stenosis plus pacing-induced tachycardia (CSPT) and the recovery after reperfusion was examined in anesthetized dogs. SOD-POE or saline was administered i.v. 30 min before reperfusion. Changes in hemodynamic variables and SS by CSPT were similar in both groups. However, the SOD-POE group showed improved recovery of SS compared with the control group. Results indicate that oxygenderived free radicals may partially be involved in the genesis of myocardial dysfunction after CSPT-induced regional ischemia.
- 公益社団法人 日本薬理学会の論文
著者
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Nakasone Junko
Department Of Pharmacology School Of Medicine Faculty Of Medicine University Of The Ryukyus
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Noguchi Katsuhiko
Department Of Pharmacalogy School Of Medicine Faculty Of Medicine University Of The Ryukyus
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Sakanashi Matao
Department Of Pharmacology And Department Of Pediatrics School Of Medicine University Of The Ryukyus
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Kinjo Noriko
Department of Biology, College of Liberal Arts and Sciences, Tokyo Medical and Dental University
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OJIRI Yoshihiko
Laboratory of Physiology and Pharmacology, School of Health Sciences, Faculty of Medicine, University of the Ryukyus
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NOGUCHI Katsuhiko
Department of Pharmacology, School of Medicin, University of the Ryukyus
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Moromizato Hidehiko
Department of Obstetrics & Gynecology, School of Medicine, Faculty of Medicine, University of the Ryukyus
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MOROMIZATO Hidehiko
Departments of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, University of the Ryukyus
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OJIRI Yoshihiko
Laboratory of Physiology and Pharmacology, School of Health Sciences, University of the Ryukyus
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OJIRI Yoshihiko
Laboratory of Physiology and Pharmacology, School of Health Sciences
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