Inhibition of Constrictor Responses of Dog Coronary Artery by Atropine : A Possible Effectiveness of Atropine on Variant Form of Angina Pectoris

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A possible effectiveness of atropine on variant form of angina pectoris was investigated using the left circumflex coronary arterial strips of dogs. Acetylcholine 10-5-10-3Gm/ml dose-dependently constricted the isolated arterial strips during potassium-contracture in 6 cases, and repetitive applications of acetylcholine could produce the similar contractions to the control. In 18 strips atropine 10-6Gm/ml significantly depressed the contractions of coronary arteries induced by acetylcholine 10-5-10-3Gm/ml. In 5 arterial strips atropine 10-6Gm/ml significantly inhibited norepinephrine-induced responses of these arteries, and by 10-5Gm/ml further suppression of these responses was obtained. The results suggest that atropine may suppress the contractile responses of the coronary artery induced by acetylcholine and norepinephrine through a muscarinic-receptor blocking action and simultaneously partly through an adrenergic alpha-receptor blocking action.
International Heart Journal刊行会の論文