FURTHER INVESTIGATIONS ON POTASSIUM-INDUCED AUTOMATICITY OF ISOLATED HUMAN RENAL ARTERY
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概要
- 論文の詳細を見る
Experiments were designed to investigate generation of automaticity of isolated human renal arteries induced by administration of potassium <I>in vitro</I>. Helical strips of human renal arteries showed marked oscillations in the potassium-induced contractions which persisted for 2 hr. Indomethacin and aspirin dose-dependently inhibited these oscillations. Tranylcypromine and mepacrine also had an inhibitory action on the oscillations of the strips induced by potassium. In the strips which reached a steady state 2 hr after administration of potassium, phospholipase A<SUB>2</SUB> and bradykinin produced marked oscillations. Our results indicate that human renal arteries can generate automaticity in the contractions induced by potassium, and that such automaticity may be related to the biosynthesis of prostaglandins.
- 社団法人 日本薬理学会の論文
著者
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UEDA SHOICHI
Department of Urology, Kumamoto University
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SAKANASHI Matao
Department of Pharmacology, School of Medicine, Faculty of Medicine, University of the Ryukyus
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IKEGAMI Keiichi
Department of Chemical Engineering and Materials Science, Faculty of Engineering, Doshisha Universit
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Ueda Shoichi
Department Of Electronics Faculty Of Technology Kanazawa University
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Sakanashi Matao
Department Of Pharmacology And Department Of Pediatrics School Of Medicine University Of The Ryukyus
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YONEMURA Ken-ichi
Department of Physiology and Pharmacology, Kumamoto University Medical School
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Ikegami Keiichi
Department Of Biological Sciences Tokyo Metropolitan University
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IKEGAMI Keiichi
Department of Urology, Kumamoto University Medical School
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UEDA Shoichi
Department of Urology, Kumamoto University Medical School
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YONEMURA Ken-ichi
Department of Physiology, Kumamoto University Medical School
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