Effects of Tandospirone Citrate and Oxazolam on Pharmacokinetics of Valproic Acid Following Oral Administration of Sodium Valproate to Rats
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概要
- 論文の詳細を見る
The drug interactions between tandospirone citrate, a non-benzodiazepine antianxiety drug, and oxazolam, a minor benzodiazepine tranquilizer and antianxiety agent, and valpronic acid (VPA), an anti-convulsant, were studied in rats. When tandospirone citrate or citric acid was administered orally immediately following oral administration (p.o.) of sodium valproate (VPA-Na), the plasma VPA levels were significantly lower than those in the control. In addition, pharmacokinetic parameters such as plasma VPA concentration and area under the plasma concentration-time curve up to 3 hr (AUC) were significantly decreased. However, when tandospirone citrate was administered intraperitonally, or both it and oxazolam were administered orally with VPA-Na, the VPA pharmacokinetic parameters were unchanged. These results suggest that decreases in plasma VPA concentrations (including those for AUC) may be due to a reduction in VPA-Na adsorption from the intestinal tract due to tandospirone citrate.
- 日本医療薬学会の論文
- 2007-06-10
著者
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Hobara Narumi
Department Of Life Science Okayama University Of Science
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SAKANASHI Mayuko
Department of Pharmacology, School of Medicine, Faculty of Medicine, University of the Ryukyus
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SAKANASHI Matao
Department of Pharmacology, School of Medicine, Faculty of Medicine, University of the Ryukyus
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OHSHIRO SUSUMU
Department of Pharmacy, University of the Ryukyus Hospital
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Ohshiro Susumu
Department Of Hospital Pharmacy Faculty Of Medicine University Of The Ryukyus
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Sakai M
Hokkaido Univ. Sapporo Jpn
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Sakai M
Olympus Optical Co. Ltd. Tokyo
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Sakai M
Univ. Tokyo Tokyo Jpn
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Sakai Masayuki
Department Of Hospital Pharmacy Faculty Of Medicine University Of The Ryukyus
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Hobara Norio
Department Of Hospital Pharmacy Faculty Of Medicine University Of The Ryukyus
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Kameya Hiromasa
Department of Hospital Pharmacy, Faculty of Medicine, University of the Ryukyus
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Hokama Nobuo
Department of Hospital Pharmacy, Faculty of Medicine, University of the Ryukyus
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Hokama Nobuo
Department Of Hospital Pharmacy Faculyt Of Medicine University Of The Ryukyus
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Kameya Hiromasa
Department Of Hospital Pharmacy Faculty Of Medicine University Of The Ryukyus
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Sakanashi M
Department Of Pharmacology School Of Medicine Faculty Of Medicine University Of The Ryukyus
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Sakanashi Matao
Department Of Pharmacology And Department Of Pediatrics School Of Medicine University Of The Ryukyus
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Sakanashi Matao
Department Of Pharmacology:2nd Department Of Internal Medicine:school Of Medicine Faculty Of Medicin
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Hobara Narumi
Department Of Clinical Pharmaceutical Science Faculty Of Pharmaceutical Science Graduate School Of B
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