RESPONSIVENESS AND HIGH-ENERGY PHOSPHATE METABOLISM OF ISOLATED DOG CORONARY ARTERIES
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概要
- 論文の詳細を見る
The relationship between responsiveness and high-energy phosphate metabolism was observed in isolated dog coronary arterial strips before and after equilibration, under aerobic conditions. The strips responded slowly to potassium, norepinephrine, isoproterenol and 5-hydroxytryptamine before being equilibrated but did respond quickly to these drugs after being equilibrated for 1 hour under aerobic conditions. The contents of ATP, creatine phosphate (CP) and lactate were not significantly altered before and after equilibration for 1 hr. It is proposed that, before being equilibrated under aerobic conditions, coronary arteries may be unable to utilize ATP and CP due to injury of contractile or relaxant mechanisms resulting in a weak vascular responsiveness.
- 社団法人 日本薬理学会の論文
著者
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SAKANASHI Matao
Department of Pharmacology, School of Medicine, Faculty of Medicine, University of the Ryukyus
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HIGUCHI MAKIE
Department of Pharmacology, School of Medicine, University of the Ryukyus Hospital
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Higuchi Makie
Department Of Pharmacology And Department Of Pediatrics School Of Medicine University Of The Ryukyus
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Takenaka Fumio
Department Of Pharmacology
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Sakanashi Matao
Department Of Pharmacology And Department Of Pediatrics School Of Medicine University Of The Ryukyus
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HIGUCHI Makie
Department of Pharmacology, Kumamoto University Medical School
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TAKENAKA Fumio
Department of Pharmacology, Kumamoto University Medical School
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