MODE OF ACTION OF EPINEPHRINE AND ACETYLCHOLINE ON CORONARY BLOOD FLOW IN ISOLATED PERFUSED CAT HEART

概要

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Recent evidence for a constrictor response of coronary bed to epinephrine (1-3) and <I>nor</I>epinephrine (4), and for a dilator action to acetylcholine (5) appears to be controversial to the accepted view that sympathetic (adrenergic) impulses produce vasodilation and vagal (cholinergic), vasoconstriction (6). The variability of the data from experiments of many workers (7-9) may be due partly to differences in technic and species employed, and in part, difficulty in analyzing the action of these drugs upon coronaries and the myocardium.<BR>Because of the importance of the nervous control on the coronary vascular bed the effects of the above transmitters should be elucidated further by using appropriate technics. In a previous paper published in this journal (10), we suggested the applicability of the rolling circular manometer system (11-13) for the study of the action of drugs upon the coronary circulation. The present experiments were performed to provide additional evidence of the effects of adrenergic as well as cholinergic drugs on the coronary blood flow of the isolated perfused cat heart using the newly designed method mentioned above.
公益社団法人日本薬理学会の論文