EFFECTS OF PENTOBARBITAL ANESTHESIA ON THE PLASMA CATECHOLAMINES AND RENIN ACTIVITY AS REFLECTED IN THE HEMODYNAMIC CHANGES IN DOGS
スポンサーリンク
概要
- 論文の詳細を見る
Correlation between hemodynamic changes and plasma catecholamines or renin activity were studied in dogs anesthetized with pentobarbital, 30 mg/kg, i.v. Pentobarbital increased heart rate in all cases regardless of changes in plasma catecholamines, and the increase was not depressed fully by propranolol. Blood pressure (BP) showed a transient decline just after pentobarbital injection and then elevated gradually to one of three levels 30-60 min after anesthesia. In low (62±4 mmHg, Mean±S.E.) and very high BP (169±7 mmHg), plasma norepinephrine (NE) showed low (305±55→89±22 pg/ml) and high levels (296±54→372±106 pg/ml), respectively, which probably reflect the neurosympathetic activities. In moderately high BP (112±4mmHg), however, the hypertension did not necessarily reflect changes in plasma NE. When the level before anesthesia was 108-164 pg/ml, plasma NE increased, whereas it decreased when the level was 182-374 pg/ml. I n either case, the level was fixed within 117-182 (154±6) pg/ml. Plasma renin activity increased after anesthesia and maintained for at least 2 hr. However, the increase were observed regardless of the BP level, and moderately high BP was not depressed by an angiotensin II antagonist. Participation of angiotensin in these sustained BP cases seems unlikely. Plasma epinephrine reflecting adrenalmedullary activity was decreased markedly in all cases, and the low level lasted for at least 2 hr. Changes in plasma dopamine are related to those in plasma NE, and the origin seems to be the same.
- 社団法人 日本薬理学会の論文
著者
-
Higuchi Makie
Department Of Pharmacology And Department Of Pediatrics School Of Medicine University Of The Ryukyus
-
Asakawa Takeo
Department Of Pharmacology Saga Medical School
-
ASAKAWA Takeo
Department of Pharmacology I, Osaka University School of Medicine
関連論文
- Survey on Undergraduate and Postgraduate Education for Clinical Pharmacology in the Departments of Pharmacy at University and College Hospitals
- A Comparison of Enzyme Activity for Energy Production in the Myocardium and Conduction System
- Effect of Verapamil on the Transmural Energy Metabolism in the Isoproterenol-induced Myocardial Lesion
- RESPONSIVENESS AND HIGH-ENERGY PHOSPHATE METABOLISM OF ISOLATED DOG CORONARY ARTERIES
- EFFECTS OF Ko 1366 ON CORONARY CIRCULATION AND MYOCARDIAL METABOLISM : (Part III)
- HYPOPERFUSION WITH NOREPINEPHRINE INJURY AND REPERFUSION INJURY IN NORMAL AND DIABETIC RAT HEARTS
- Participation of Coronary Perfusion Pressure in Transmural Energy Metabolism in the Hypoperfused Canine Heart
- Catecholamine Sensitivity and Cardiac Myosin ATPase Activity in Dogs Treated with Propranolol
- EFFECTS OF PENTOBARBITAL ANESTHESIA ON THE PLASMA CATECHOLAMINES AND RENIN ACTIVITY AS REFLECTED IN THE HEMODYNAMIC CHANGES IN DOGS
- Effects of 2-Nicotinamidoethyl Nitrate (SG-75, Nicorandil) on Indomethacin-Induced Contractions of Isolated Dog Coronary Arteries
- Effects of 4-Aminopyridine and Tetraethylammonium on Relaxant Responses of Isolated Dog Coronary Arteries to 2-Nicotinamidoethyl Nitrate (SG-75)
- Mechanism and Properties of Inhibition of Purified Rat Brain Adenylate Cyclase by G Protein βγ - Subunits
- F--INDUCED CHANGES AND ITS REVERSAL BY ITP IN MEMBRANE TURBIDITY AND ADENYLATE CYCLASE ACTIVITY OF CHICK BRAIN MICROSOMES
- Regulation of Guanylate Cyclase by ATP and Dithiothreitol in Rat Lung Membrane : Involvement of an Insensitive and a Sensitive State to ATP/Dithiothreitol-Stimulation
- STUDIES ON THE FUNCTIONAL ROLE OF ADENOSINE 3, 5-MONOPHOSPHATE, HISTAMINE AND PROSTAGLANDIN E1 IN THE CENTRAL NERVOUS SYSTEM
- Improvement of hypoperfusion with norepinephrine injury by ex vivo insulin in isolated diabetic rat hearts.
- Effects of nipradilol, a new .BETA.-adrenoceptor blocking agent with vasodilating properties, on transmural energy metabolism in the underperfused canine heart.
- Effects of Denopamine with or without Diltiazem on the Ischemic Heart of Anesthetized Dogs.
- Ouabain-Like Na+,K+-ATPase Inhibitory Activity of a Plasma Extract in Normal Pregnancy and Pregnancy Induced Hypertension.
- G Protein .BETA..GAMMA.-Subunits Inhibit Purified Adenylate Cyclase Independent of the Activation by Ca2+ and Calmodulin.