F<SUP>-</SUP>-INDUCED CHANGES AND ITS REVERSAL BY ITP IN MEMBRANE TURBIDITY AND ADENYLATE CYCLASE ACTIVITY OF CHICK BRAIN MICROSOMES
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概要
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The activation of adenylate cyclase by NaF was dependent on the previous incubation time and the concentration of F<SUP>-</SUP>. The activation by F<SUP>-</SUP> was irreversible and Mg<SUP>2+</SUP> was required for the maximum effect. Turbidity of microsome suspension was also greatly increased by F<SUP>-</SUP> plus Mg<SUP>2+</SUP> . These effects on adenylate cyclase and membrane turbidity were specific for F<SUP>-</SUP> and F<SUP>-</SUP>-saturation curves for both were similar, though Mg<SUP>2+</SUP>-saturation curves for both were dissimilar. The increase in turbidity induced by F<SUP>-</SUP> plus Mg<SUP>2+</SUP> was rapidly reversed by ATP, GTP, ITP, UTP and CTP. However, ITP only, among all the triphospho-nucleotides tested, reversed the activity of adenylate cyclase previously activated by NaF plus MgCl<SUB>2</SUB>. The activity of the enzyme reversed by ITP was not, however, re-enhanced by the presence of NaF in the assay medium. These results suggest the possibility that F<SUP>-</SUP> induces a change in the membrane structure itself, and this change can be reversed by incubation with ITP. Consequently, adenylate cyclase may be conformed either to an activated or an unactivated state.
- 社団法人 日本薬理学会の論文
著者
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Yoshida Hiroshi
Department Of Biophysics Graduate School Of Science Kyoto University
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Asakawa Takeo
Department Of Pharmacology Saga Medical School
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Yoshida Hiroshi
Departmen Of Radiology School Of Medicine Asahikawa Medical University
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ASAKAWA Takeo
Department of Pharmacology I, Osaka University School of Medicine
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