DEVELOPMENTAL CHANGE OF BETA-ADRENERGIC RECEPTORS IN RAT BRAIN
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概要
- 論文の詳細を見る
The developmental change of beta-adrenergic receptors in rat whole brain, except the cerebellum, was studied by binding assays with (-) <SUP>3</SUP>H-dihydroalprenolol. The synaptic membrane fraction, prepared from 2-day-old and 6-week-old rat brains, had binding sites for (-) <SUP>3</SUP>H-dihydroalprenolol, which seemed to represent physiological beta-adrenoceptors. The maximal binding capacity and the dissociation constant for (-) <SUP>3</SUP>H-dihydroalprenolol of the synaptic membrane fraction did not vary with the age of the rats, but the yield of synaptic membrane fraction from the brain of 2-day-old rats was much less. Therefore, the total number of binding sites was less in 2-day-old rats. In addition, there was a significant difference in the inhibitory effects of 1-isoproterenol on binding of (-) <SUP>3</SUP>H-dihydroalprenolol to the synaptic membrane fractions in the 2-day as compared to the tissues from the 6-week-old aminals. The developmental changes in the number and nature of beta-adrenoceptors may result in expression of catecholamine-sensitive adenylate cyclase activity.
- 社団法人 日本薬理学会の論文
著者
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WATANABE YASUHIRO
Department of Neurology, Matsue Red Cross Hospital
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Itoh Tadao
Department Of Clinical Pharmacology Faculty Of Medicine Tottori University
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Yoshida Hiroshi
Department Of Biophysics Graduate School Of Science Kyoto University
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Watanabe Yasuhiro
Department Of Neurology Institute Of Neurological Sciences Tottori University
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Watanabe Yasuhiro
Department Of Clinical Biochemistry Hokkaido College Of Pharmacy
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Yoshida Hiroshi
Departmen Of Radiology School Of Medicine Asahikawa Medical University
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