Effect of Growth Factor on GTPase-Activating Protein (Ras GAP) in Chinese Hamster Ovary Cells
スポンサーリンク
概要
- 論文の詳細を見る
GTPase-activating proteins (GAPs) stimulate the hydrolysis of GTP bound to small G-proteins and regulate the signal transduction pathway. Changes in the expression of p21-Ras p120-GAP induced by growth factor treatment were examined in cultured Chinese hamster ovary (CHO) and human choriocarcinoma (BeWo) cells. Expression of p120-GAP and GAP activity were measured. Fetal bovine serum induced a significant increased level of GAP in CHO cells, but did not increase GAP in BeWo cells. The results suggest that growth factors affect Ras GAP expression in CHO cells, while they do not in other cells such as BeWo cells.
- 社団法人 日本薬理学会の論文
著者
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UMEKAGE Tadashi
Department of Psychiatry, Graduate School of Medicine, University of Tokyo
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WATANABE YASUHIRO
Department of Neurology, Matsue Red Cross Hospital
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NAKATA Hiroko
Department of Surgery, Institute of Clinical Medicine, University of Tsukuba
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Sasa Hidenori
Department of Obstetrics and Gynecology, National Defence Medical College
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Sasa Hidenori
Department Of Obstetrics And Gynecology National Defense Medical College
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Nakata Hiroko
Department Of Cardiovascular Surgery Tsukuba Medical Center Hospital
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Nakata Hiroko
Department Of Pharmacology National Defense Medical College
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Sasa Hidenori
Department Of Perinatal And Maternal Medicine National Defense Medical College
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NAMIMA Misako
Department of Pharmacology, National Defense Medical College
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TOMIYAMA Koji
Department of Pharmacology, National Defense Medical College
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ARIMURA Shinya
Department of Pharmacology, National Defense Medical College
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KOBAYASHI Mitsunao
Department of Perinatal and Maternal Medicine, National Defense Medical College
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Tomiyama K
National Defense Medical Coll. Saitama Jpn
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Arimura Shinya
Department Of Anesthesia Self Defense Force Central Hospital
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Arimura Shinya
Department Of Pharmacology National Defense Medical College
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Tomiyama Koji
Department Of Cancer And Thoracic Surgery Okayama University School Of Medicine
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Namima M
Department Of Pharmacology National Defense Medical College
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Kobayashi Mitsunao
Department Of Perinatal And Maternal Medicine National Defense Medical College
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Umekage Tadashi
Department Of Pharmacology National Defense Medical College
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Watanabe Yasuhiro
Department Of Neurology Matsue Red Cross Hospital
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Watanabe Yasuhiro
Department Of Pharmacology National Defense Medical College
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Watanabe Yasuhiro
Department Of Neurology Institute Of Neurological Sciences Tottori University
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Watanabe Yasuhiro
Department Of Electronic Science And Engineering Kyoto University
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Watanabe Yasuhiro
Department Of Clinical Biochemistry Hokkaido College Of Pharmacy
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Umekage Tadashi
Department Of Neuropsychiatry Graduate School Of Medicine University Of Tokyo
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