Modification by cGMP of glibenclamide-sensitive K+ currents in Xenopus oocytes.
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概要
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Effects of sodium nitroprusside, 8-bromo cGMP and methylene blue on the glibenclamidesensitive K<SUP>+</SUP> current evoked by K<SUP>+</SUP> channel openers in <I>Xenopus</I> oocytes were studied. Sodium nitroprusside (0.1-1 mM, an activator of guanylate cyclase)enhanced by 20-50% the K<SUP>+</SUP> currents induced by KRN2391, nicorandil and cromakalim (K<SUP>+</SUP> channel openers). 8-Bromo cGMP (1 mM)also increased the K<SUP>+</SUP> current by 40-60%. Methylene blue (10 μM, an inhibitor of guanylate cyclase)irreversibly blocked the K<SUP>+</SUP> current by about 20-30%. These results suggest that the activation of glibenclamide-sensitive K<SUP>+</SUP> channels by K<SUP>+</SUP> channel openers is modulated either positively or negatively by intracellular cGMP in oocytes.
- 公益社団法人 日本薬理学会の論文
著者
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Okamoto Koichi
Deparment Of Neurology Gunma University School Of Medicine
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Sakuta Hidenari
Department Of Internal Medicine Self-defense Forces Central Hospital
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Watanabe Yasuhiro
Department Of Clinical Biochemistry Hokkaido College Of Pharmacy
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Watanabe Yasuhiro
Department of Pharmacology, National Defense Medical College
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Sakuta Hidenari
Department of Pharmacology, National Defense Medical College
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