Both Wortmannin and Simvastatin Inhibit the Adipogenesis in 3T3-L1 Cells During the Late Phase of Differentiation
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概要
- 論文の詳細を見る
As we reported previously, both wortmannin and lovastatin inhibit the differentiation in 3T3-L1 cells when these drugs were applied during the insulin-induced cell differentiation. In the present study, 3T3-L1 cells were treated with wortmannin and simvastatin after the completion of the insulin-stimulation, and differentiation was found to be significantly decreased by these drugs. This suggests intracellular signaling pathways play roles in the differentiation of 3T3-L1 cells even after the completion of the insulin-stimulation and also suggests that not only the early phase (day 0 to day 2) but also the late phase (day 2 to day 4) of differentiation is important for the differentiation of the cells.
- 社団法人 日本薬理学会の論文
- 1999-08-01
著者
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WATANABE YASUHIRO
Department of Neurology, Matsue Red Cross Hospital
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TOMIYAMA Koji
Department of Pharmacology, National Defense Medical College
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Tomiyama Koji
Department Of Pharmacology National Defense Medical College
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Tomiyama Koji
Department Of Cancer And Thoracic Surgery Okayama University School Of Medicine
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NISHIO Eisuke
Department of Pharmacology, National Defense Medical College
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Nishio Eisuke
Department Of Pharmacology National Defense Medical College
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Watanabe Yasuhiro
Department Of Neurology Matsue Red Cross Hospital
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Watanabe Yasuhiro
Department Of Pharmacology National Defense Medical College
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Watanabe Yasuhiro
Department Of Clinical Biochemistry Hokkaido College Of Pharmacy
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