Study on a New Index of Fetal Respiratory Function : a Novel Optical Analysis of the Amniotic Fluid by the Vacuum-dried Infrared Attenuated Total Reflection (ATR) Method

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概要

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• For the purpose of detecting fetal pulmonary maturity with real-time convenience but reliable accuracy, infrared spectrophotometry of amniotic fluid lipids was introduced using our newly developed optical device. The peak areas at the wave number of 1740cm^<-1> on the infrared spectra (called "PA_<1740>") were measured in 29 specimens sampled from 29 pregnant women, and compared with the Lecithin/Sphingomyelin (L/S) ratio of the same samples. Statistical analysis revealed that the PA_<1740> was almost as reliable as the L/S ratio, and these indices illustrated pulmonary immaturity in cases with a PA_<1740><0.9 and an L/S ratio <2.0. PA_<1740> is absolutely independent of the effect on the concentration of lecithin in the amniotic fluid because of a combination of the vacuum-drying process and the absorbance correction, and can be completed in less than 20 minutes from sampling of the amniotic fluid by a very simple manipulation. In conclusion, the new index, PA_<1740>, will be a more practical method for prediction of the fetal pulmonary maturity than methods such as the well known L/S ratio.

• 東海大学の論文

著者

• Kikuchi Makoto

  Department of Medical Engineering, National Defense Medical College Graduate School

• Kikuchi Makoto

  Department Of Applied Physics Faculty Of Technology Tohoku Gakuin University

• Okino Haruka

  Department Of Physiology Tokai University

• Okino Haruka

  Department Of Physiology 2 School Of Medicine Tokai University

• ARAI Tsunenori

  Department of Medical Engineering National Defense Medical College

• Arai Tsunenori

  Department Of Applied Physics And Physico-informatics Faculty Of Science And Technology Keio Univers

• KOBAYASHI Mitsunao

  Department of Perinatal and Maternal Medicine, National Defense Medical College

• KOBAYASHI Hisaaki

  Tateyama Air Medical Service Unit, Japan Maritime Self-Defense Force

• Kobayashi Mitsunao

  Department Of Perinatal And Maternal Medicine National Defense Medical College

• Kobayashi Hisaaki

  Tateyama Air Medical Service Unit Japan Maritime Self-defense Force

• Kikuchi Makoto

  Department Of Physiology School Of Medicine Tokai University

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