The Link Between Free Radicals and Myocardial Injury : SYMPOSIUM ON PATHOPHYSIOLOGY IN THE EARLY STAGE OF ACUTE MYOCARDIAL INFARCTION AND ITS TREATMENT : 51th Annual Scientific Session of the Japanese Circulation Society
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概要
- 論文の詳細を見る
In the first part of this study, oxygen derived redicals (O_2-radical) were indirectly demonstrated as causative agents for ischemia/reperfusion injury by showing myocardial protection of radical scavengers. In 19 open chest digs, the left anterior descending coronary artery was occluded for 90 min and subsequently reperfused for 60 min. Group A received SOD (15000 U/kg), catalase (5 mg/kg) and 20% mannitol (18 ml/kg) via the left atrium starting 15 min pre-occlusion and ending 15 min after reperfusion. Group B received infusion of saline and served as control. The severity of myocardial injury was evaluated by epicardial ECG, hemodynamics, echo cardiographical asynergy area and left ventricular wall thickness, histopathological findings and magnitude of necrotic area. Group A demonstrated less injury than group B in most of the parameters. In particular, ratios of necrotic to perfused areas determined by dual fluorescence methods were significantly limited in group A (34.1 ± 12.0 vs 66.0 ± 11.3%), indirectly verifying that the O_2-radicals play an important role in the genesis of ischema/reperfusion injury. In the second part of the study, the direct measurement of radicals in freeze-clamped myocardium was reported using electron spin resonance (ESR) spectroscopy. With this method, it was not possible to demonstrate the generation of O_2-radicals in ischemic/reperfused myocardium. However, the data suggested that coenzyme Q_<10> anion radical, which exists in the normal myocardium, might provide an index of tissue injury.
- 社団法人日本循環器学会の論文
- 1988-07-20
著者
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HORI Shingo
Department of Emergency & Critical Care Medicine, School of Medicine, Keio University
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Masuda Takashi
Department of Rehabilitation, School of Allied Health Sciences, Kitasato University
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Nakazawa Hiroe
Department Of Cardiovascular Research Research Institute Of Environmental Medicine Nagoya University
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Aoki Nobuo
Department Of Medical Technology Nagoya University School Of Health Sciences
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Ban Kazunobu
Dept Of Physiology 2 Tokai Univ.
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Ban Kazunobu
Department Of Physiology Tokai University
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Ban Kazunobu
Department Of Cardiology Tokai University
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Hori Shingo
Department Of Cardiovascular Surgery Keio University School Of Medicine
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Hori Shingo
Department Of Physiology Keio University
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Hori Shingo
Dept Of Physiology Tokai University
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Okino Haruka
Dept Of Physiology 2 Tokai Univ.
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Okino Haruka
Department Of Physiology Tokai University
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Okino Haruka
Department Of Physiology 2 School Of Medicine Tokai University
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Masuda Takashi
Department Of Medicine Kitasato Univ.school Of Medicine
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Okino Haruka
Dept Of Physiology Tokai University
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ICHIMORI KOHJI
Department of Physiology, Tokai University
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MINEZAKI KENRHO
Department of Physiology, Tokai University
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Ichimori Koji
Dept of Physiology 2 Tokai Univ.
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Ichimori Koji
Department Of Physiology Tokai University
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Aoki Nobuo
Department Of Physiology Kyorin University
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Ichimori Kohji
Dept Of Physiology 2 Tokai Univ.
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Ichimori Kohji
Department Of Physiology 2 Tokai University School Of Medicine
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Nakazawa Hiroe
Dept Of Physiology 2 Tokai Univ.
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Minezaki Kenrho
Dept Of Physiology 2 Tokai Univ.
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Masuda Takashi
Department Of Physiology Kitasato University
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Aoki Nobuo
Department Of Hygiene Hamamatsu University School Of Medicine
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Masuda Takashi
Departmant Of Emergency & Critical Care Medicine Kitasato University School Of Medicine
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Ichimori Kohji
Department of Chemistry, Faculty of Science, Kyoto University
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AOKI Nobuo
Department of Epidemiology, National Cardiovascular Center
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