Vanadate Improves Cardiac Function and Myocardial Energy Metabolism in Diabetic Rat Hearts
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概要
- 論文の詳細を見る
Vanadium mimicking the metabolic effects of insulin is known to decrease serum glucose levels and to influence glucose metabolism in diabetes mellitus. However, it is unclear whether vanadium ameliorates the metabolic disorder in diabetic hearts causing myocardial dysfunction. The purpose of this study was to assess the effects of vanadium on cardiac performance and energy metabolism in diabetic rat hearts. Four groups of Wistar rats were studied: untreated control rats (group C, n = 8), vanadate-treated rats (group V, n = 10), untreated diabetic rats (group DM, n = 9) induced by streptozotocin, and vanadate-treated diabetic rats (group DMV, n = 8). Vanadate-treated rats drank a 1.5 mM sodium orthovanadate (Na3VO4) solution during a 4 week diabetic condition. Hearts were perfused with Krebs-Henseleit buffer after the diabetic duration. After the maximum left ventricular dP/dt and cardiac efficiency were calculated, the myocardial contents of ATP and creatine phosphate (P-Cr) and myocardial energy metabolism were assessed by cytosolic phosphorylation potential. Peak positive and negative dP/dt, and cardiac efficiency decreased significantly in group DM compared with group C, while there were no significant differences between groups C and DMV. The myocardial contents of ATP (μmol/g wet heart) and P-Cr (μmol/g wet heart), and cytosolic phosphorylation potential (M-1) increased from 2.72 ± 0.46, 1.45 ± 0.58, and 3,530 ± 1,220 in group DM to 3.88 ± 0.76, 3.81 ± 1.36, and 11,200 ± 2,400 in group DMV, respectively. It is concluded that vanadium restored the production of high energy phosphates in the myocardium and improved myocardial dysfunction by regulating metabolic processes in diabetic rat hearts.
- Japanese Heart Journal Associationの論文
著者
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Izumi Tohru
Department Of Cardio-angiology Kitasato University School Of Medicine
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Izumi Tohru
北里大学 医療衛生学部リハビリテーション学科
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Masuda Takashi
Department of Rehabilitation, School of Allied Health Sciences, Kitasato University
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Noda Chiharu
Department of Internal Medicine, Kitasato University School of Medicine
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Sato Kiyotaka
Department of Internal Medicine, Kitasato University School of Medicine
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Ikeda Kazuko
Department of Internal Medicine, Kitasato University School of Medicine
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Shimohama Takao
Department of Internal Medicine, Kitasato University School of Medicine
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Matsuyama Narihisa
Department of Internal Medicine, Kitasato University School of Medicine
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Noda Chiharu
Department Of Cardio-angiology Kitasato University School Of Medicine
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Matsuyama Narihisa
Department Of Cardiology Yamato Municipal Hospital
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Ikeda Kazuko
Department Of Internal Medcine Kitasato University School Of Medicine
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Masuda Takashi
Departmant Of Emergency & Critical Care Medicine Kitasato University School Of Medicine
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Izumi Tohru
Department Of Angio-cardiology Kitasato University School Of Medicine
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Shimohama Takao
Department Of Angio-cardiology Kitasato University School Of Medicine
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Sato Kiyotaka
Department of Food Technology and Chemistry, Faculty of Fisheries and Animal Husbandry, Hiroshima University
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IKEDA Kazuko
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Masuda Takashi
Department of Rehabilitation, Kitasato University School of Allied Health Sciences Kanagawa
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