Angiotensin II Receptor Antagonist Attenuates Expression of Aging Markers in Diabetic Mouse Heart
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概要
- 論文の詳細を見る
Background Diabetes mellitus is an independent risk factor for heart failure. Diabetes mellitus causes other age-related cardiovascular diseases. We assessed the hypothesis that hearts from diabetic animals are associated with accelerated aging processes. We also examined the effect of an angiotensin II receptor blocker (ARB) on the expression of senescence-associated molecules. Methods and Results We administered an ARB (candesartan 10mg/kg per day) or saline to diabetic db/db or control db/+ mice. The treatment was started when mice were 10-weeks-old, and continued for 15 weeks. Systolic function was impaired in db/db mice and candesartan improved cardiac function. The amount of phosphorylated Akt and S6 was decreased in saline-treated db/db mice, and candesartan treatment partially preserved phosphorylation. The amount of p21, p27, p53 or Rb was increased in the heart tissue of saline treated db/db mice. Candesartan treatment completely suppressed the increases of p21, p27, p53 and Rb. Conclusions An ARB improved cardiac function of diabetic animals, and this was accompanied by decreases of senescence-associated molecules in the myocardium. ARB may be a modality for heart failure patients with diabetes mellitus.
- 社団法人日本循環器学会の論文
- 2006-03-20
著者
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Shioi Tetsuo
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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Izumi Tohru
Department Of Cardio-angiology Kitasato University School Of Medicine
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TAKAHASHI Keiko
Department of Biochemistry, Showa University School of Medicine
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YOSHIDA Yuki
Department of Neurosurgery, Iwate Medical University
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Kosugi Rie
Department of Cardio-angiology, Kitasato University School of Medicine
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Machida Yoji
Department of Cardio-angiology, Kitasato University School of Medicine
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Machida Yoji
Department Of Cardio-angiology Kitasato University School Of Medicine
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Shioi Tetsuo
Department Of Cardiovascular Medicine Kyoto University
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Shioi Tetsuo
Department Of Cardiology And Internal Medicine Kitasato University School Of Medicine
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Watanabe-maeda Kayo
Department Of International Medicine And Cardiology Kitasato University School Of Medicine
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Kosugi Rie
Department Of Cardio-angiology Kitasato University School Of Medicine
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Shioi Tetsuo
Department Of Cardiology Kyoto University School Of Medicine
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Shioi Tetsuo
Department Of Cardiology Graduate School Of Medicine Kyoto University
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Yoshida Yuki
Department Of Cardio-angiology Kitasato University School Of Medicine
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Izumi Tohru
Department Of Cardio-angiology Kitasato University School Of Medcine
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Takahashi Keiko
Department Of Internal Medicine And Cardiology Kitasato University School Of Medicine
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Yoshida Yuki
Department Of Bioscience Tokyo University Of Agriculture
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Takahashi Keiko
Department Of Applied Chemistry Faculty Of Engineering Tokyo Institute Of Polytechnics
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Izumi Tohru
Department Of Angio-cardiology Kitasato University School Of Medicine
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